Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005)

Name: Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005)
SKU: AFC-TAB-005
Rating: 5 (1 reviews)

CAT#: AFC-TAB-005

This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant monoclonal antibody to Human ErbB2. It is a monoclonal antibody that interferes with the HER2/neu receptor. Its main use is to treat certain breast cancers.
The HER receptors are proteins that are embedded in the cell membrane and communicate molecular signals from outside the cell (molecules called EGFs) to inside the cell, and turn genes on and off. The HER proteins stimulate cell proliferation. In some cancers, notably certain types of breast cancer, HER2 is over-expressed, and causes cancer cells to reproduce uncontrollably.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

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Specifications

Immunogen
NIH 3T3/HER2-3400 cells are used to immunize BALB/c mice.

Host Species
Human

Derivation
Humanized (from mouse)

Type
ADCC enhanced antibody

Species Reactivity
Human

Applications
FC, IP, ELISA, Neut, FuncS, IF

Conjugate
Unconjugated

Trade name
Herclon, Trastuzumab

Generic Name
Trastuzumab

Related Disease
Breast cancers overexpressing ERBB2, metastatic

Product Property

Purity
>95% by SDS-PAGE

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Alternative Names
ERBB2; v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian); NGL, v erb b2 avian erythroblastic leukemia viral oncogene homolog 2

Gene ID
2064

UniProt ID
P04626

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Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Datasheet

Datasheet - AFC-TAB-005.pdf

MSDS

MSDS - AFC-TAB-005.pdf

COA

Certificate of Analysis Lookup

To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.

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Protocol & Troubleshooting

Immunofluorescence (IF)

We have outlined the assay protocols, covering reagents, solutions, procedures, and troubleshooting tips for common issues in order to better assist clients in conducting experiments with our products. View the full list of Protocol & Troubleshooting.

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CAT	Product Name	Application	Type
TAB-005	Anti-Human ErbB2 Recombinant Antibody (TAB-005)	FC, IP, ELISA, Neut, FuncS, IF, IHC	IgG1 - kappa
TAB-033CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-033CT-F(E))	ELISA, WB	Humanized Fab
TAB-038CT-F(E)	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-038CT-F(E))	WB	Humanized Fab
TAB-039CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (h1E11)	WB	Humanized antibody
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CAT	Product Name	Application	Type
TAB-761	Anti-ERBB2 Recombinant Antibody (Margetuximab)	IF, IP, Neut, FuncS, ELISA, FC, WB	IgG1 - kappa
TAB-049CT	Anti-Human HER2/neu Recombinant Antibody (ChA21)	IHC, Inhib, WB, Activ, FC	Chimeric antibody (mouse/human)
TAB-049CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21)	WB	Chimeric antibody (mouse/human)
TAB-049CT-F(E)	Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21)	WB	Chimeric antibody (mouse/human)

CAT	Product Name	Application
AGTO-G022E	Anti-ERBB2 immunotoxin 4D5 (scFv)-PE	Cytotoxicity assay, Function study
AGTO-G022D	Anti-ERBB2 immunotoxin 4D5 (scFv)-DT	Cytotoxicity assay, Function study
AGTO-G022G	Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel	Cytotoxicity assay, Function study
AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
AGTO-G022S	Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap	Cytotoxicity assay, Function study

CAT	Product Name	Application	Type
PFBL-126	Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (PFBL-126)	ELISA, WB, FuncS	Human Fab
PFBZ-041	Human Anti-ERBB2 Recombinant Antibody (clone bH1); Fab Fragment	WB, IF, FuncS	Human Fab
FAMAB-0098-YC-F(E)	Mouse Anti-ERBB2 Recombinant Antibody (clone E402); Fab Fragment	Cyt	Mouse Fab
FAMAB-0099-YC-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone CH402); Fab Fragment	Cyt	Human Fab
FAMAB-0132CQ-F(E)	Mouse Anti-ERBB2 Recombinant Antibody (clone SER4); Fab Fragment	ELISA	Mouse Fab

CAT	Product Name	Application	Type
PNBL-066	Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-066)	SPR	Llama VHH
PNBL-067	Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-067)	SPR	Llama VHH
HPAB-0201-FY	Recombinant llama Anti-ERBB2 Antibody (HPAB-0201-FY)	E	llama VHH
HPAB-0202-FY	Recombinant llama Anti-ERBB2 Antibody (HPAB-0202-FY)	E	llama VHH
HPAB-0203-FY	Recombinant llama Anti-ERBB2 Antibody	IF	llama VHH

CAT	Product Name	Application	Type
PFBC-157	Human Anti-ERBB2 Recombinant Antibody (clone F0178C1); Fab Fragment	Neut	Human Fab
HPAB-1111LY-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1111LY-S(P))	ELISA	Mouse scFv
HPAB-1112LY-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1112LY-S(P))	ELISA	Human scFv
HPAB-M0510-YC-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0510-YC-S(P))	FC, FuncS	Mouse scFv
HPAB-0193-WJ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment	ELISA	Mouse scFv

CAT	Product Name	Application	Type
TAB-034CT	Anti-Human HER2/neu Recombinant Antibody (TAB-034CT)	WB
TAB-036CT	Anti-Human HER2/neu Recombinant Antibody (6B2)	ELISA, WB
TAB-037CT	Anti-Human HER2/neu Recombinant Antibody (7C2/7F3)	ELISA, WB
TAB-270CQ	Mouse Anti-ERBB2 Recombinant Antibody (TAB-270CQ)	WB, Inhib	Mouse IgG
PABX-082-S (P)	Recombinant Human Anti-HER2 Antibody scFv Fragment (Gr6)	WB, ELISA, FuncS	scFv

CAT	Product Name	Application	Type
TAB-040CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (C6.5)	FC, IP, Block	Human antibody
TAB-042CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (CRX01)	WB	Human antibody
TAB-043CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-043CT-S(P))	ELISA, Inhibion	Human scFv
TAB-044CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (TAB-044CT-S(P))	WB, FC, IF, Funcs	Human antibody
TAB-045CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (Erbicin)	ELISA, Inhibition	Human antibody

CAT	Product Name	Application	Type
Gly-024LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-146LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-149LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
Gly-177LC	Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
MOB-0103MZ	Recombinant Mouse Anti-ERBB2 Antibody (clone C980M)	ELISA	Mouse antibody
MOB-014LC	Mouse Anti-ERBB2 Recombinant Antibody (MOB-014LC)	ELISA, FC	Mouse IgG
MOB-014LC-F(E)	Mouse Anti-ERBB2 Recombinant Antibody; Fab Fragment (MOB-014LC-F(E))	ELISA, FC	Mouse Fab
MOB-014LC-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (MOB-014LC-S(P))	ELISA, FC	Mouse scFv
FAMAB-0098YC	Mouse Anti-ERBB2 Recombinant Antibody (clone E402)	Cyt	Mouse IgG1, κ

CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
NEUT-737CQ	Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4)	Block, IP, IF, FC	Mouse IgG2a

CAT	Product Name	Application	Type
MOR-1178	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB)	IHC-P, IHC-Fr	Rabbit IgG
MOR-4586	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS)	WB	Rabbit IgG
MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application	Type
AFC-TAB-468CQ	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ)	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-053	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053)	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody
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CAT	Product Name	Application
MHC-YF419	A*02:01/Human ERBB-2 (HLYQGCQVV) MHC Pentamer	FCM
MHC-YF420	A*02:01/Human ERBB-2 (PLQPEQLQV) MHC Pentamer	FCM
MHC-YF421	A*02:01/Human ERBB-2 (PLTSIISAV) MHC Pentamer	FCM
MHC-YF422	A*02:01/Human ERBB-2 (ILLVVVLGV) MHC Pentamer	FCM
MHC-YF423	A*02:01/Human ERBB-2 (QLMPYGCLL) MHC Pentamer	FCM

CAT	Product Name	Application	Type
VS-0424-XY91	AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2)	IP, Protein Purification
VS-0724-YC1516	AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY24	Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera	FC, BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2335	Anti-ERBB2 Immunohistochemistry Kit	IHC
VS-0525-XY2336	Anti-Mouse ERBB2 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC3	Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab	ELISA	Symmetric scFv-Fab
VS-0525-YC6	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab	ELISA	Asymmetric hetero Fab
VS-0525-YC7	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA, Inhib	Asymmetric hetero HC, common LC

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