Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)

Name: Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)
SKU: Gly-024LC
Rating: 5 (1 reviews)

CAT#: Gly-024LC

This product is a mouse monoclonal antibody with N-glycosylation sites in the position 65 of light chain. The antibody 4D5 has increased binding affinity to human HER2 and can be potentially used in the treatment of breast cancer.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

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Glyco-engineering

Glycosylation site
aa65 of VL

Glycosylation Type
N-glycosylation

Activity
Increased binding affinity

Specifications

Target
HER-2 (Human epidermal growth factor receptor 2)

Host Species
Mouse

Type
Mouse antibody

Specificity
Human

Clone
4D5

Applications
ELISA

Target

Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1

Related Disease
Breast cancer

Gene ID
2064

UniProt ID
P04626

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Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - Gly-024LC.pdf

MSDS

MSDS - Gly-024LC.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application
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AGTO-G022G	Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel	Cytotoxicity assay, Function study
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CAT	Product Name	Application	Type
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
FAMAB-0132CQ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody (clone SER4); scFv Fragment	ELISA	Mouse scFv
HPAB-0010-FY-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-0010-FY-S(P))	ELISA, FC	Human scFv
HPAB-0011-FY-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-0011-FY-S(P))	Inhib	Mouse scFv
HPAB-0193-WJ-S(P)	Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment	ELISA	Mouse scFv
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MHC-CN0643	FITC-A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer	FCM, IHC
MHC-CN0644	A*02:01/Human ERBB2 (LIAHNQVRQV) MHC Tetramer	FCM, IHC
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
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