Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)

Name: Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated)
SKU: Gly-177LC
Rating: 5 (1 reviews)

CAT#: Gly-177LC

This product is a non-glycosylated humanized monoclonal antibody. The glyco-engineered antibody has high binding to all three FcyRI, FcyRI and FcyRIIb. The antibody specifically binds to human Her-2 and can be potentially used in the treatment of breast cancer.

Gene Expression

Subcellular Location Figure 1 IF staining of human cell line U-251 MG

Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg

Subcellular Location Figure 2 IF staining of human cell line A-431

Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg

Normal Tissue Figure 3 High expression in esophagus

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg

Normal Tissue Figure 4 IHC staining of human rectum

Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg

Normal Tissue Figure 5 IHC staining of human urinary bladder

Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg

Normal Tissue Figure 6 Kidney

Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg

Normal Tissue Figure 7 Breast

Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg

RNA Expression Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)

Cell lines ordered by descending RNA expression order

* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2

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Glyco-engineering

Activity
High binding to all three FcyRI, FcyRI and FcyRIIb

Specifications

Target
HER-2 (Human epidermal growth factor receptor 2)

Host Species
Human

Type
Humanized antibody

Specificity
Human

Antibody Isotype
IgG

Clone
Trastuzumab-Fc2a

Applications
ELISA

Target

Alternative Names
ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1

Related Disease
Breast cancer

Gene ID
2064

UniProt ID
P04626

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Related Diseases

Bladder Cancer

Non-small Cell Lung Cancer

Related Signaling Pathways

ErbB Signaling Pathway

Downloadable Resources

Download resources about recombinant antibody development and antibody engineering to boost your research.

Datasheet

Datasheet - Gly-177LC.pdf

MSDS

MSDS - Gly-177LC.pdf

COA

Certificate of Analysis Lookup

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CAT	Product Name	Application
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AGTO-G022R	Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA	Cytotoxicity assay, Function study
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CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
PFBL-463	Human Anti-ERBB2 Recombinant Antibody Fab Fragment (PFBL-463)	WB	Human Fab
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HPAB-0091-FY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone MIL12); Fab Fragment	ELISA	Humanized Fab
HPAB-0733LY-F(E)	Human Anti-ERBB2 Recombinant Antibody (clone AH06); Fab Fragment	ELISA	Human Fab
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CAT	Product Name	Application	Type
TAB-033CT	Human Anti-ERBB2 Recombinant Antibody (TAB-033CT)	ELISA, WB	Human IgG1, κ
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CAT	Product Name	Application	Type
TAB-034CT	Anti-Human HER2/neu Recombinant Antibody (TAB-034CT)	WB
TAB-036CT	Anti-Human HER2/neu Recombinant Antibody (6B2)	ELISA, WB
TAB-037CT	Anti-Human HER2/neu Recombinant Antibody (7C2/7F3)	ELISA, WB
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CAT	Product Name	Application	Type
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TAB-043CT-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-043CT-S(P))	ELISA, Inhibion	Human scFv
TAB-044CT-S(P)	Anti-Human HER2/neu Recombinant Antibody scFv Fragment (TAB-044CT-S(P))	WB, FC, IF, Funcs	Human antibody
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CAT	Product Name	Application	Type
Gly-024LC	Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation)	ELISA	Mouse antibody

CAT	Product Name	Application	Type
Gly-145LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-146LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-147LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-148LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody
Gly-149LC	Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation)	ELISA	Human antibody

CAT	Product Name	Application	Type
BRD-0195MZ	Chicken Anti-ERBB2 Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application	Type
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CAT	Product Name	Application	Type
MOR-1178	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB)	IHC-P, IHC-Fr	Rabbit IgG
MOR-4586	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS)	WB	Rabbit IgG
MOR-4587	Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS)	WB	Rabbit IgG

CAT	Product Name	Application
MHC-LC3036	PE-A*24:02/Human ERBB2 (SYGVTVWEL) MHC Tetramer	FCM
MHC-LC3037	PE-A*24:02/Human ERBB2 (VYMIMVKCW) MHC Tetramer	FCM
MHC-LC3050	PE-A*02:01/Human ERBB2 (ALCRWGLLL) MHC Tetramer	FCM
MHC-LC3051	APC-A*02:03/Human ERBB2 (ALCRWGLLL) MHC Tetramer	FCM
MHC-LC3061	PE-A*02:01/Human ERBB2 (CLTSTVQLV) MHC Tetramer	FCM

CAT	Product Name	Application	Type
HPAB-0021-YC-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-0021-YC-S(P))	ELISA, Neut, FC	Human scFv
HPAB-1111LY-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1111LY-S(P))	ELISA	Mouse scFv
HPAB-1112LY-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-1112LY-S(P))	ELISA	Human scFv
HPAB-M0510-YC-S(P)	Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0510-YC-S(P))	FC, FuncS	Mouse scFv
HPAB-M0073-YC-S(P)	Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0073-YC-S(P))	ELISA, FC	Human scFv

CAT	Product Name	Application	Type
HPAB-0091-FY	Human Anti-ERBB2 Recombinant Antibody (clone MIL12)	ELISA	Humanized IgG
HPAB-0742-WJ	Human Anti-ERBB2 Recombinant Antibody (HPAB-0742-WJ)	ELISA	Humanized IgG
HPAB-0743-WJ	Human Anti-ERBB2 Recombinant Antibody (HPAB-0743-WJ)	ELISA	Humanized IgG
HPAB-0744-WJ	Human Anti-ERBB2 Recombinant Antibody (HPAB-0744-WJ)	ELISA	Humanized IgG
HPAB-0745-WJ	Human Anti-ERBB2 Recombinant Antibody (HPAB-0745-WJ)	ELISA	Humanized IgG

CAT	Product Name	Application	Type
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AFC-TAB-761	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761)	IF, IP, Neut, FuncS, ELISA, FC	ADCC enhanced antibody
AFC-TAB-005	Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005)	FC, IP, ELISA, Neut, FuncS, IF	ADCC enhanced antibody

CAT	Product Name	Application	Type
VS-0424-XY91	AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2)	IP, Protein Purification
VS-0724-YC1516	AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516)	IP, Protein Purification

CAT	Product Name	Application	Type
VS-0125-FY24	Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera	FC, BI	Human IgG1, scFv-Fc

CAT	Product Name	Application	Type
VS-0225-XY108	CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2)	FC	Mouse IgG1, kappa

CAT	Product Name	Application	Type
VS-0425-YC430	Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430)	ELISA, FC, Neut, Cell-uptake

CAT	Product Name	Application	Type
VS-0525-XY2335	Anti-ERBB2 Immunohistochemistry Kit	IHC
VS-0525-XY2336	Anti-Mouse ERBB2 Immunohistochemistry Kit	IHC

CAT	Product Name	Application	Type
VS-0525-YC3	Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab	ELISA	Symmetric scFv-Fab
VS-0525-YC6	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab	ELISA	Asymmetric hetero Fab
VS-0525-YC7	Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC	ELISA, Inhib	Asymmetric hetero HC, common LC

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