Recombinant Anti-human ERBB2 Intrabody [Tat]
CAT#: IAB-B008(T)
Recombinant anti-ERBB2 intrabody in fusion with HIV Tat targetes to the lumen of the endoplasmic reticulum prevent the transit of EGFR or the related ErbB2 molecule to the cell surface, thereby inactivating their transforming potential, expressed in CHO cells.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-251 MG
Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1060/169_D12_1_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line A-431
Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1338/if_selected.jpg
Normal Tissue
Figure 3 High expression in esophagus
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/1383/4682_B_5_1_val_selected.jpg
Normal Tissue
Figure 4 IHC staining of human rectum
Immunohistochemical staining of human rectum shows weak cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/ihc_selected.jpg
Normal Tissue
Figure 5 IHC staining of human urinary bladder
Immunohistochemical staining of human urinary bladder shows moderate cytoplasmic and membranous positivity in urothelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/ihc_selected.jpg
Normal Tissue
Figure 6 Kidney
Collecting ducts Staining: Low Intensity: Moderate Quantity: <25% Distal tubules Staining: Low Intensity: Moderate Quantity: <25%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/43/1054_A_7_5.jpg
Normal Tissue
Figure 7 Breast
Glandular cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Myoepithelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/20416/45831_B_3_4.jpg
RNA Expression
Figure 8 RNA cell line category: Group enriched (OE19, SK-BR-3)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000141736-ERBB2
❮
❯
Specifications
- Immunogen
- human erb-b2 receptor tyrosine kinase 2
- Host Species
- human
- Type
- scFv-Tat
- Cell Penetrating Peptide
- TAT
TAT was able to deliver different proteins, such as horseradish peroxidase and RNase A across cell membrane into the cytoplasm in different cell lines in vitro. The size range of proteins with effective delivery is from 30kDa to 120-150kDa. In one study, TAT-fused proteins are rapidly internalized by lipid raft−dependent macropinocytosis using a transducible TAT−Cre recombinase reporter assay on live cells. In another study, a TAT-fused protein was delivered into mitochondria of breast cancer cells and decreased the survival of breast cancer cells, which showed capability of TAT-fusion proteins to modulate mitochondrial function and cell survival. However, very few in vivo studies have succeeded. In one study, in vivo delivery of TAT- or penetratin-crosslinked Fab fragments yielded varied organ distributions and an overall increase in organ retention, which showed tissue localization.
- Species Reactivity
- human
- Applications
- Formats of immunological tests: Immunocytochemistry; Neutralization; Functional studies
Product Property
- Purity
- 90–95% (SDS-PAGE)
- Storage
- Store at -20°C for long-term storage. Store at 4°C for up to one month. Avoid freeze/thaw cycles.
Target
- Alternative Names
- ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1
- Gene ID
- 2064
- UniProt ID
- P04626
REVIEWS AND Q&AS
CITATIONS
RESOURCES
DOWNLOADS
RELATED PRODUCTS
Inquiry
Navs
Customer Review
There are currently no Customer reviews or questions for IAB-B008(T). Click the button above to contact us or submit your feedback about this product.
Submit Your Publication
Published with our product? Submit your paper and receive a 10% discount on your next order! Share your research to earn exclusive rewards.
Related Diseases
Bladder Cancer
Non-small Cell Lung Cancer
Related Signaling Pathways
ErbB Signaling Pathway
Downloadable Resources
Download resources about recombinant antibody development and antibody engineering to boost your research.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
See other products for "ERBB2"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| IAB-B008(A) | Recombinant Anti-human ERBB2 Intrabody [(D-Arg)9] | IF, FC, FuncS | scFv-(D-Arg)9 |
| IAB-B008(G) | Recombinant Anti-human ERBB2 Intrabody [+36 GFP] | WB, ICC, FuncS | scFv-(+36GFP) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-761 | Anti-ERBB2 Recombinant Antibody (Margetuximab) | IF, IP, Neut, FuncS, ELISA, FC, WB | IgG1 - kappa |
| TAB-049CT | Anti-Human HER2/neu Recombinant Antibody (ChA21) | IHC, Inhib, WB, Activ, FC | Chimeric antibody (mouse/human) |
| TAB-049CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
| TAB-049CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (ChA21) | WB | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-053 | Anti-Human ERBB2 Recombinant Antibody (TAB-053) | FuncS, IF, Neut, ELISA, FC, IP, WB | IgG1 - kappa |
| TAB-033CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-033CT-S(P)) | ELISA, WB | Human scFv |
| TAB-038CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-038CT-S(P)) | WB | Humanized scFv |
| TAB-039CT-S(P) | Anti-Human HER2/neu Recombinant Antibody scFv Fragment (h1E11) | WB | Humanized antibody |
| TAB-041CT-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-041CT-S(P)) | ELISA, WB | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AGTO-G022E | Anti-ERBB2 immunotoxin 4D5 (scFv)-PE | Cytotoxicity assay, Function study | |
| AGTO-G022D | Anti-ERBB2 immunotoxin 4D5 (scFv)-DT | Cytotoxicity assay, Function study | |
| AGTO-G022G | Anti-ERBB2 immunotoxin 4D5 (scFv)-Gel | Cytotoxicity assay, Function study | |
| AGTO-G022R | Anti-ERBB2 immunotoxin 4D5 (scFv)-RTA | Cytotoxicity assay, Function study | |
| AGTO-G022S | Anti-ERBB2 immunotoxin 4D5 (scFv)-Sap | Cytotoxicity assay, Function study |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PNBL-066 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-066) | SPR | Llama VHH |
| PNBL-067 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-067) | SPR | Llama VHH |
| PNBL-069 | Recombinant Anti-HER2 VHH Single Domain Antibody (PNBL-069) | ELISA | Llama VHH |
| TAB-032CT | Anti-Human HER2/neu Single Domain Antibody, Research Grade Biosimilar | WB | Single domain antibody |
| TAB-046CT | Anti-Human HER2/neu Single Domain Antibody (TAB-046CT), Research Grade Biosimilar | ELISA, Inhibition, FC | Single domain antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-463 | Human Anti-ERBB2 Recombinant Antibody scFv Fragment (PSBL-463) | WB | Human scFv |
| HPAB-0193-WJ-S(P) | Mouse Anti-ERBB2 Recombinant Antibody (clone 6H8); scFv Fragment | ELISA | Mouse scFv |
| HPAB-M0073-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0073-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0074-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0074-YC-S(P)) | ELISA, FC | Human scFv |
| HPAB-M0075-YC-S(P) | Human Anti-ERBB2 Recombinant Antibody; scFv Fragment (HPAB-M0075-YC-S(P)) | ELISA, FC | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-034CT | Anti-Human HER2/neu Recombinant Antibody (TAB-034CT) | WB | |
| TAB-036CT | Anti-Human HER2/neu Recombinant Antibody (6B2) | ELISA, WB | |
| TAB-037CT | Anti-Human HER2/neu Recombinant Antibody (7C2/7F3) | ELISA, WB | |
| TAB-270CQ | Mouse Anti-ERBB2 Recombinant Antibody (TAB-270CQ) | WB, Inhib | Mouse IgG |
| TAB-270CQ-S(P) | Mouse Anti-ERBB2 Recombinant Antibody; scFv Fragment (TAB-270CQ-S(P)) | WB, Inhib | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-040CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (C6.5) | ELISA, WB | Human antibody |
| TAB-042CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (CRX01) | WB | Human antibody |
| TAB-043CT-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (TAB-043CT-F(E)) | ELISA, Inhibion | Human Fab |
| TAB-044CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (TAB-044CT-F(E)) | WB | Human antibody |
| TAB-045CT-F(E) | Anti-Human HER2/neu Recombinant Antibody Fab Fragment (Erbicin) | ELISA, Inhibition | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-024LC | Recombinant Anti-Human ERBB2 Antibody (Fab glycosylation) | ELISA | Mouse antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-145LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-146LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-147LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-148LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| Gly-149LC | Recombinant Anti-Human ERBB2 Antibody (Fc glycosylation) | ELISA | Human antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| Gly-177LC | Recombinant Anti-Human ERBB2 Antibody (Non-glycosylated) | ELISA | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0103MZ | Recombinant Mouse Anti-ERBB2 Antibody (clone C980M) | ELISA | Mouse antibody |
| HPAB-M0073-YC | Human Anti-ERBB2 Recombinant Antibody (HPAB-M0073-YC) | ELISA, FC | Human IgG |
| HPAB-M0074-YC | Human Anti-ERBB2 Recombinant Antibody (HPAB-M0074-YC) | ELISA, FC | Human IgG |
| HPAB-M0075-YC | Human Anti-ERBB2 Recombinant Antibody (HPAB-M0075-YC) | ELISA, FC | Human IgG |
| HPAB-M0076-YC | Human Anti-ERBB2 Recombinant Antibody (HPAB-M0076-YC) | ELISA, FC | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| BRD-0195MZ | Chicken Anti-ERBB2 Polyclonal IgY | WB | Chicken antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NEUT-737CQ | Mouse Anti-ERBB2 Recombinant Antibody (clone 7.16.4) | Block, IP, IF, FC | Mouse IgG2a |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1178 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone DS1178AB) | IHC-P, IHC-Fr | Rabbit IgG |
| MOR-4586 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH99DS) | WB | Rabbit IgG |
| MOR-4587 | Hi-Affi™ Rabbit Anti-ERBB2 Recombinant Antibody (clone TH100DS) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| AFC-TAB-468CQ | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-468CQ) | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
| AFC-TAB-053 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-053) | FuncS, IF, Neut, ELISA, FC, IP | ADCC enhanced antibody |
| AFC-TAB-761 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-761) | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
| AFC-TAB-005 | Afuco™ Anti-ERBB2 ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-005) | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-M0073-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0073-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-M0074-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0074-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-M0075-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0075-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-M0076-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0076-YC-F(E)) | ELISA, FC | Human Fab |
| HPAB-M0077-YC-F(E) | Human Anti-ERBB2 Recombinant Antibody; Fab Fragment (HPAB-M0077-YC-F(E)) | ELISA, FC | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0424-XY91 | AbPlus™ Anti-ERBB2 Magnetic Beads (3.F2) | IP, Protein Purification | |
| VS-0724-YC1516 | AbPlus™ Anti-Erbb2 Magnetic Beads (VS-0724-YC1516) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0125-FY24 | Human Anti-ERBB2 (clone 1.18.1) scFv-Fc Chimera | FC, BI | Human IgG1, scFv-Fc |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY108 | CytoStream™ Mouse Anti-ERBB2 Recombinant Antibody (clone 24D2) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC430 | Recombinant Anti-ERBB2 Vesicular Antibody, EV Displayed (VS-0425-YC430) | ELISA, FC, Neut, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2335 | Anti-ERBB2 Immunohistochemistry Kit | IHC | |
| VS-0525-XY2336 | Anti-Mouse ERBB2 Immunohistochemistry Kit | IHC |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-YC3 | Recombinant Anti-ERBB2 Biparatopic Antibody, Symmetric scFv-Fab | ELISA | Symmetric scFv-Fab |
| VS-0525-YC6 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero Fab | ELISA | Asymmetric hetero Fab |
| VS-0525-YC7 | Recombinant Anti-ERBB2 Biparatopic Antibody, Asymmetric hetero HC-LC | ELISA, Inhib | Asymmetric hetero HC, common LC |
Specific Inquiry
Add to compare
See Our Custom Production in Action
Popular Products
Application: FC, IP, ELISA, Neut, FuncS, IF, WB
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
-3.jpg)
Application: ELISA, IHC, FC, WB, IF, IA
Application: ELISA, PD, Activ, PK, Stim
Application: ELISA, FC, Inhib, IHC-Fr, WB, IP
Application: ELISA, FC, WB, Inhib, IHC
Application: Inhib, FC, WB
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
Send Inquiry
This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.
