Rabbit Anti-GCLC Recombinant Antibody (VS3-FY2718)
CAT#: VS3-FY2718
The anti-GCLC antibody is specifically engineered to target mouse GCLC protein. It shows capability of cross-reacting with rat. This monoclonal antibody proves valuable in disease research related to Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To and Myocardial Infarction.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36360/432_C2_2_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, nucleoli & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9569/931_H5_3_selected.jpg
Normal Tissue
Figure 3 IHC staining of human esophagus
Immunohistochemical staining of human esophagus shows strong cytoplasmic positivity in squamous epithelial cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36359/ihc_selected.jpg
Normal Tissue
Figure 4 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36359/84384_A_5_6.jpg
Normal Tissue
Figure 5 Lymph node
Non-germinal center cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/9569/24577_A_9_8.jpg
Normal Tissue
Figure 6 Liver
Hepatocytes Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36359/84384_A_9_4.jpg
Normal Tissue
Figure 7 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/36359/84384_A_7_5.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (A549, Hep G2, OE19, RT4)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000001084-GCLC
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Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Glutamate-cysteine ligase catalytic subunit of mouse and rat origins
- Species Reactivity
- Mouse, Rat
- Applications
- WB, IP
- Conjugate
- Unconjugated, FITC
- Related Disease
- Gamma-Glutamylcysteine Synthetase Deficiency, Hemolytic Anemia Due To and Myocardial Infarction
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Immunoprecipitation: 1/20
Western Blot: 1/500-1/1000
Target
- Alternative Names
- Glutamate-Cysteine Ligase Catalytic Subunit; Gamma-Glutamylcysteine Synthetase; GCS Heavy Chain; EC 6.3.2.2; Gamma-ECS; GLCLC
- Gene ID
- 2729
- UniProt ID
- P48506
- Sequence Similarities
- Belongs to the glutamate--cysteine ligase type 3 family.
- Post Translation Modifications
- Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- XP_054211163.1; NP_001184044.1; NP_001489.1
- Function
- Catalyzes the ATP-dependent ligation of L-glutamate and L-cysteine and participates in the first and rate-limiting step in glutathione biosynthesis.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GCLC"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-1995MZ | Recombinant Mouse Anti-Human GCLC Antibody | ICC, IF, WB | Mouse antibody |
| MRO-0640-CN | Rabbit Anti-GCLC Recombinant Antibody (clone JA08-03) | WB, IHC, FC | Rabbit IgG |
| VS3-FY583 | Recombinant Rabbit Anti-GCLC Antibody (clone R03-9D9) | WB | Rabbit IgG |
| VS3-FY584 | Recombinant Rabbit Anti-GCLC Antibody (clone R08-2F5) | WB, IP | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1417 | Hi-Affi™ Rabbit Anti-GCLC Recombinant Antibody (clone DS1417AB) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-1024-XY217 | Mouse Anti-NHP GCLC Recombinant Antibody (clone OTI1A3) | WB, IHC, IF | Mouse IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY2767 | Anti-Rat GCLC Immunohistochemistry Kit | IHC |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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