Recombinant human antibody to Tat. B1E3 reacted with two peptides, 19-53 and 44-61 and neutralized only native Tat.
Figure 1 Immunoreactivity of HMAbs to rTat.
rTat submitted to
SDS-PAGE and Western blotting was detected by antiserum from a
Tat-immunized human volunteer.
Moreau, E., Hoebeke, J., Zagury, D., Muller, S., & Desgranges, C. (2004). Generation and characterization of neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 Tat antigen. Journal of virology, 78(7), 3792-3796.
Figure 2 Neutralization of Tat transactivation by HMAb.
LTR-dependent CAT production by HL3T1 cells was measured after preincubation
of active rTat with increasing concentrations of antibodies.
Moreau, E., Hoebeke, J., Zagury, D., Muller, S., & Desgranges, C. (2004). Generation and characterization of neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 Tat antigen. Journal of virology, 78(7), 3792-3796.
Figure 3 Inhibition of HIV-1 IIIB replication by HMAbs.
Production of p24 HIV antigen by H9 chronically infected cells in the presence of HMAbs or control antibody was measured after 3 days of
culture.
Moreau, E., Hoebeke, J., Zagury, D., Muller, S., & Desgranges, C. (2004). Generation and characterization of neutralizing human monoclonal antibodies against human immunodeficiency virus type 1 Tat antigen. Journal of virology, 78(7), 3792-3796.
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• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
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• Animal-free production
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CAT | Product Name | Application | Type |
---|---|---|---|
PSBL-565 | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 11H6H1); scFv Fragment | ELISA, Neut | Mouse scFv |
MRO-4310CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone B1E3); scFv Fragment | ELISA, Neut | Human scFv |
MRO-4311CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G1); scFv Fragment | WB, IP, Neut | Human scFv |
MRO-4312CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G2); scFv Fragment | WB, IP, Neut | Human scFv |
MRO-4313CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J1); scFv Fragment | WB, IP, Neut | Human scFv |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-1023CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 02-001) | WB, IP | Mouse IgG2b |
MRO-1024CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 02-002) | WB, IP | Mouse IgG1 |
MRO-1025CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 02-010) | WB, IP | Mouse IgM |
MRO-1026CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 02-012) | WB, IP | Mouse IgG1 |
MRO-1027CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 1) | RIPA, IHC-P, IHC-Fr, ELISA, WB | Mouse IgG1 |
CAT | Product Name | Application | Type |
---|---|---|---|
MRO-4310CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone B1E3); Fab Fragment | ELISA, Neut | Human Fab |
MRO-4311CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G1); Fab Fragment | WB, IP, Neut | Human Fab |
MRO-4312CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G2); Fab Fragment | WB, IP, Neut | Human Fab |
MRO-4313CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J1); Fab Fragment | WB, IP, Neut | Human Fab |
MRO-4314CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J3B2); Fab Fragment | ELISA, Neut | Human Fab |
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For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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