Human Anti-HIV-1 Tat Recombinant Antibody (clone G2) (CAT#: MRO-4312CQ)
Recombinant human antibody to Tat. G2 binds strongly to soluble rTAT protein and to denatured rTAT, suggesting that the epitope is linear. G2 recognized HIV-1 clade B Tat proteins Bru and HXB2, but did not bind to clade E (CM240), clade C (92Br), clade D.
Specific Inquiry
WB
Figure 1 sFv105 or sFv105-KDEL specific binding to the HIV-1 glycoprotein in cells.
sFv105 is not coprecipitated with unrelated proteins.
Marasco, W. A., Haseltine, W. A., & Chen, S. (1993). Design, intracellular expression, and activity of a human anti-human immunodeficiency virus type 1 gp120 single-chain antibody. Proceedings of the National Academy of Sciences, 90(16), 7889-7893.
FC
Figure 2 Effect of PI3K pharmacological inhibitors on the antiapoptotic effect of Tat.
The percentage of apoptotic KS cells subjected to the TUNEL assay after 24 h of
incubation with different stimuli.
Deregibus, M. C., Cantaluppi, V., Doublier, S., Brizzi, M. F., Deambrosis, I., Albini, A., & Camussi, G. (2002). HIV-1-Tat protein activates phosphatidylinositol 3-kinase/AKT-dependent survival pathways in Kaposi's sarcoma cells. Journal of Biological Chemistry, 277(28), 25195-25202.
Specifications
- Host Species
- Human
- Type
- Human IgG1, κ
- Specificity
- Recognizes HIV-1 Tat
- Species Reactivity
- HIV-1
- Clone
- G2
- Applications
- WB, FC
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- The HIV-1 Tat antibody has been reported in applications of Western Blot, Flow Cytometry.
Target
- Alternative Names
- TAT; p14; Tat; Transactivating regulatory protein; HIV-1
- Gene ID
- 155871
- UniProt ID
- P04608
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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See other products for "Clone G2"
See other products for "HIV-1 Tat"
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-565 | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 11H6H1); Fab Fragment | ELISA, Neut | Mouse Fab |
| MRO-4310CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone B1E3); Fab Fragment | ELISA, Neut | Human Fab |
| MRO-4311CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G1); Fab Fragment | WB, IP, Neut | Human Fab |
| MRO-4312CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G2); Fab Fragment | WB, IP, Neut | Human Fab |
| MRO-4313CQ-F(E) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J1); Fab Fragment | WB, IP, Neut | Human Fab |
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-1840CQ | Mouse Anti-HIV-1 Tat Recombinant Antibody (clone 8C182) | ICC, WB | Mouse IgG1 |
| MRO-4310CQ | Human Anti-HIV-1 Tat Recombinant Antibody (clone B1E3) | Neut, Inhib, WB | Human IgG1, κ |
| MRO-4311CQ | Human Anti-HIV-1 Tat Recombinant Antibody (clone G1) | WB, IP, Neut | Human IgG1, κ |
| MRO-4313CQ | Human Anti-HIV-1 Tat Recombinant Antibody (clone J1) | Neut, WB | Human IgG1, λ |
| MRO-4314CQ | Human Anti-HIV-1 Tat Recombinant Antibody (clone J3B2) | ELISA, Neut | Human IgG1, λ |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MRO-4310CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone B1E3); scFv Fragment | ELISA, Neut | Human scFv |
| MRO-4311CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G1); scFv Fragment | WB, IP, Neut | Human scFv |
| MRO-4312CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone G2); scFv Fragment | WB, IP, Neut | Human scFv |
| MRO-4313CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J1); scFv Fragment | WB, IP, Neut | Human scFv |
| MRO-4314CQ-S(P) | Human Anti-HIV-1 Tat Recombinant Antibody (clone J3B2); scFv Fragment | ELISA, Neut | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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