Anti-HPN (clone mab25) Recombinant Antibody Coupled Liposome (VS-1024-FY299)
CAT#: VS-1024-FY299
Anti-HPN antibody conjugated liposomes hold significant potential in prostate cancer research by enabling targeted delivery of therapeutics directly to cancer cells, thereby enhancing treatment efficacy while minimizing off-target effects. Additionally, their ability to serve as carriers for imaging agents could improve early detection and monitoring of tumor progression, paving the way for more personalized treatment strategies.
Gene Expression
Normal Tissue
Figure 1 Cerebral cortex
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glial cells
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
Neuronal cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_B_7_5.jpg
Normal Tissue
Figure 2 Colon
Endothelial cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Glandular cells
Staining:High
Intensity: Strong
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_7_3.jpg
Normal Tissue
Figure 3 Liver
Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Hepatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_8_4.jpg
Normal Tissue
Figure 4 Kidney
Cells in glomeruli
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Cells in tubules
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/6804/19524_A_4_6.jpg
RNA Expression
Figure 6 RNA cell line category: Group enriched (EFO-21, Hep G2, T-47d)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000105707-HPN
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More Infomation
Specifications
- Potential Clinical Applications
- Prostate cancer
Product Composition
- Clone
- mab25
- Antibody Type
- IgG
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This is a recombinant mouse monoclonal antibody that was specifically engineered to target HPN. Designed through advanced genetic techniques, this antibody exhibits high specificity and affinity for HPN, making it a valuable tool for both research and therapeutic applications. Its unique properties enable it to effectively bind to HPN, providing insights into the role of this protein in various biological processes.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- HPN
- Introduction
- This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.
- Alternative Names
- TMPRSS1
- Full Name
- Hepsin
- Gene ID
- 3249
- UniProt ID
- P05981
- Sequence Similarities
- Belongs to the peptidase S1 family.
- Cellular Localization
- Cell membrane; Single-pass type II membrane protein; Apical cell membrane; Single-pass type II membrane protein
- Post Translation Modifications
- Glycosylation at Asn112 ( NX_P05981 [NX_P05981-1] )
Modification sites at PhosphoSitePlus ( P05981 )
Glycosylation from GlyGen (P05981) 1 site, 13 N-linked glycans (1 site)
- Protein Refseq
- XP_016882220.1; XP_016882221.1; XP_047294697.1; XP_054176782.1; XP_054176783.1
- Function
- Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, 21875933).
Plays a role in cell growth and maintenance of cell morphology.
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Downloadable Resources
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Datasheet
MSDS
COA
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| CAT | Product Name | Application | Type |
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| MOB-2151z | Mouse Anti-HPN Recombinant Antibody (clone 19A1) | WB, ELISA, IP | Mouse IgG2a, κ |
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| HPAB-0224-LSX | Human Anti-HPN Recombinant Antibody (clone mAb55) | ELISA, FC, Inhib | Humanized IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PSBL-125 | Human Anti-HPN Recombinant Antibody scFv Fragment (PSBL-125) | WB, ELISA, FuncS | Human scFv |
| HPAB-0223-LSX-S(P) | Mouse Anti-HPN Recombinant Antibody (clone 25); scFv Fragment | ELISA | Mouse scFv |
| HPAB-0224-LSX-S(P) | Human Anti-HPN Recombinant Antibody (clone mAb55); scFv Fragment | ELISA | Humanized scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| PFBL-125 | Human Anti-HPN Recombinant Antibody Fab Fragment (PFBL-125) | WB, ELISA, FuncS | Human Fab |
| HPAB-0223-LSX-F(E) | Mouse Anti-HPN Recombinant Antibody (clone 25); Fab Fragment | ELISA | Mouse Fab |
| HPAB-0224-LSX-F(E) | Human Anti-HPN Recombinant Antibody (clone mAb55); Fab Fragment | ELISA | Humanized Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-029CT | Anti-Human Hepsin Recombinant Antibody (hH35) | ELISA, WB | Humanized antibody |
| TAB-031CT | Human Anti-HPN Recombinant Antibody (TAB-031CT) | WB | Humanized IgG |
| TAB-029CT-S(P) | Anti-Human Hepsin Recombinant Antibody scFv Fragment (hH35) | ELISA, WB | Humanized antibody |
| TAB-031CT-S(P) | Human Anti-HPN Recombinant Antibody; scFv Fragment (TAB-031CT-S(P)) | WB | Humanized scFv |
| TAB-029CT-F(E) | Anti-Human Hepsin Recombinant Antibody Fab Fragment (hH35) | ELISA, WB | Humanized antibody |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-030CT | Anti-Human Hepsin Recombinant Antibody (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| TAB-030CT-S(P) | Anti-Human Hepsin Recombinant Antibody scFv Fragment (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| TAB-030CT-F(E) | Anti-Human Hepsin Recombinant Antibody Fab Fragment (Mab2.7.35) | ELISA, Inhibition, FC | Chimeric antibody (mouse/human) |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC349 | Recombinant Anti-HPN Vesicular Antibody, EV Displayed (VS-0425-YC349) | ELISA, FC, Cell-uptake |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY3274 | Anti-HPN Immunohistochemistry Kit | IHC |
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