Anti-HPN (clone mab25) Recombinant Antibody Coupled Liposome (VS-1024-FY299) (CAT#: VS-1024-FY299)

• Potential Clinical Applications
• Prostate cancer

• Clone
• mab25

• Antibody Type
• IgG

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This is a recombinant mouse monoclonal antibody that was specifically engineered to target HPN. Designed through advanced genetic techniques, this antibody exhibits high specificity and affinity for HPN, making it a valuable tool for both research and therapeutic applications. Its unique properties enable it to effectively bind to HPN, providing insights into the role of this protein in various biological processes.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• HPN

• Introduction
• This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants.

• Alternative Names
• TMPRSS1

• Full Name
• Hepsin

• Gene ID
• 3249

• UniProt ID
• P05981

• Sequence Similarities
• Belongs to the peptidase S1 family.

• Cellular Localization
• Cell membrane; Single-pass type II membrane protein; Apical cell membrane; Single-pass type II membrane protein

• Post Translation Modifications
• Glycosylation at Asn112 ( NX_P05981 [NX_P05981-1] )
  Modification sites at PhosphoSitePlus ( P05981 )
  Glycosylation from GlyGen (P05981) 1 site, 13 N-linked glycans (1 site)

• Protein Refseq
• XP_016882220.1; XP_016882221.1; XP_047294697.1; XP_054176782.1; XP_054176783.1

• Function
• Serine protease that cleaves extracellular substrates, and contributes to the proteolytic processing of growth factors, such as HGF and MST1/HGFL (PubMed:15839837, 21875933).
  Plays a role in cell growth and maintenance of cell morphology.

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