Human Anti-IL12RB1 Recombinant Antibody (clone FAb4)
CAT#: VS-0724-YC2
Antibody clone Fab4 is a class of antagonistic antibody against IL-12Rβ1 at an interface that does not overlap with the cytokine binding site. Fab4 binds IL-12Rβ1 at the interface of D3 and D4, which is indeed not part of a cytokine- or receptor-receptor interface.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/74414/1688_B12_33_selected.jpg
RNA Expression
Figure 2 RNA cell line category: Cell line enhanced (Daudi, HDLM-2, Karpas-707, U-698)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000096996-IL12RB1
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Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Human IL-12Rβ1
- Species Reactivity
- Human
- Clone
- FAb4
- Applications
- ELISA, Antagonist
Product Property
- Purification
- Protein A purified
- Purity
- >95% as determined by SDS-PAGE and SEC-HPLC analysis
- Buffer
- PBS, pH 7.4
- Preservative
- No preservatives
- Storage
- Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- CD212; IMD30; IL12RB; IL-12R-BETA1
- Gene ID
- 3594
- UniProt ID
- P42701
- Long Name
- il12rbeta1
- Sequence Similarities
- Belongs to the type I cytokine receptor family. Type 2 subfamily.
- Cellular Localization
- Membrane; Single-pass type I membrane protein
- Post Translation Modifications
- Glycosylation at Asn121, Asn329, Asn346, Asn352, Asn442, and Asn456.
- Protein Refseq
- XP_006722804.2; XP_011526268.1; XP_011526269.1; XP_011526270.1; XP_011526271.1
- Function
- Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction.
Associated with IL12RB2 it forms a functional, high affinity receptor for IL12.
Associates also with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Isotype Control
- CAT
- Product Name
Secondary Antibody
- CAT
- Product Name
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0084-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb4); scFv Fragment | ELISA | Human scFv |
| HPAB-0852-CN-S(P) | Human Anti-IL12RB1 Recombinant Antibody; scFv Fragment (HPAB-0852-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0853-CN-S(P) | Human Anti-IL12RB1 Recombinant Antibody; scFv Fragment (HPAB-0853-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-0854-CN-S(P) | Human Anti-IL12RB1 Recombinant Antibody; scFv Fragment (HPAB-0854-CN-S(P)) | ELISA, FC | Human scFv |
| HPAB-674-FY-S(P) | Mouse Anti-IL12RB1 Recombinant Antibody (clone mAb1); scFv Fragment | ELISA | Mouse scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0852-CN | Human Anti-IL12RB1 Recombinant Antibody (HPAB-0852-CN) | ELISA, FC | Human IgG4 |
| HPAB-0853-CN | Human Anti-IL12RB1 Recombinant Antibody (HPAB-0853-CN) | ELISA, FC | Human IgG4 |
| HPAB-0845-FY | Human Anti-IL12RB1 Recombinant Antibody (clone mAb1) | ELISA | Human IgG |
| HPAB-0847-FY | Human Anti-IL12RB1 Recombinant Antibody (clone mAb7) | ELISA | Human IgG |
| HPAB-0848-FY | Human Anti-IL12RB1 Recombinant Antibody (clone mAb10) | ELISA | Human IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0852-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0852-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0853-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0853-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0854-CN-F(E) | Human Anti-IL12RB1 Recombinant Antibody; Fab Fragment (HPAB-0854-CN-F(E)) | ELISA, FC | Human Fab |
| HPAB-0845-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb1); Fab Fragment | ELISA | Human Fab |
| HPAB-0848-FY-S(P) | Human Anti-IL12RB1 Recombinant Antibody (clone mAb10); Fab Fragment | ELISA | Human Fab |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC1416 | AbPlus™ Anti-IL12RB1 Magnetic Beads (VS-0724-YC1416) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0225-XY127 | CytoStream™ Mouse Anti-IL12RB1 Recombinant Antibody (VS-0225-XY127) | FC | Mouse IgG2a, kappa |
| VS-0225-XY128 | CytoStream™ Mouse Anti-IL12RB1 Recombinant Antibody (VS-0225-XY128) | FC | Mouse IgG1, kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0425-YC541 | Recombinant Anti-IL12RB1 Vesicular Antibody, EV Displayed (VS-0425-YC541) | ELISA, FC, Cell-uptake |
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