Rabbit Anti-LOX Recombinant Antibody (clone R09-6N5) (CAT#: VS3-XY3419)
The rabbit recombinant antibody specifically binds to human LOX (Lysyl oxidase). It also has cross-reactivity against mouse and rat LOX. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20, 1/50-1/100 and 1/50-1/200, respectively.
Specific Inquiry
Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human
(Immunofluorescent staining of human cell line BJ shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43930/1742_E9_18_cr5804930fbb88d_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43930/1742_E9_18_cr5804930fbb88d_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (BJ, fHDF/TERT166, HSkMC, U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113083-LOX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113083-LOX
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LOX
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-6N5
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Aortic Aneurysm, Familial Thoracic 10
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- AAT10
- Gene ID
- 4015
- Long Name
- Lysyl oxidase
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen. (P28300-LYOX_HUMAN)
Glycosylation at Asn81, Thr89, Asn97, Thr113, Thr120, Ser130, Thr131, Ser132, Asn144, and Thr413 (NX_P28300 [NX_P28300-1])
Modification sites at PhosphoSitePlus (P28300)
Glycosylation from GlyConnect LYOX_HUMAN (816)
Glycosylation from GlyGen (P28300) 14 sites, 15 N-linked glycans (4 sites), 3 O-linked glycans (9 sites)
- Protein Refseq
- NP_001304002.1
- Function
- Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787).
Regulator of Ras expression.
May play a role in tumor suppression.
Plays a role in the aortic wall architecture.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
See other products for "LOX"
Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-629 | Recombinant Anti-human LOX Antibody | ELISA, WB, IF, FuncS | IgG |
| MHH-629 | Recombinant Human Anti-human LOX Antibody | FC, RIA, Biosensors, FuncS | IgG |
| MRO-0936-CN | Recombinant Rabbit Anti-LOX Monoclonal Antibody (JU30-23) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY1015 | Mouse Anti-LOX Recombinant Antibody (clone 624CT23.7.3) | WB | Mouse IgG2b |
| VS3-XY1016 | Mouse Anti-LOX Recombinant Antibody (clone 2G5) | WB, IP, IF, IHC | Mouse IgG1 |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-629-F(E) | Recombinant Anti-human LOX Antibody Fab Fragment | IF, FC, FuncS | Fab |
| MHH-629-F(E) | Recombinant Human Anti-human LOX Antibody Fab Fragment | ELISA, FuncS | Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-629-S(P) | Recombinant Anti-human LOX Antibody scFv Fragment | FC, Neut, Funcs | scFv |
| MHH-629-S(P) | Recombinant Human Anti-human LOX Antibody scFv Fragment | ELISA, WB, FuncS | scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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