Rabbit Anti-LOX Recombinant Antibody (clone R09-6N5) (CAT#: VS3-XY3419)
The rabbit recombinant antibody specifically binds to human LOX (Lysyl oxidase). It also has cross-reactivity against mouse and rat LOX. It has been determined using Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry, Immunocytochemistry or Immunofluorescence. The recommended dilutions of Western Blot, Immunohistochemistry-Paraffin, Immunoprecipitation, Flow cytometry and Immunofluorescence is 1/500-1/1000, 1/50-1/100, 1/20, 1/50-1/100 and 1/50-1/200, respectively.
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Subcellular Location and Protein Expression
RNA Expression
Figure 1 IF staining of human
(Immunofluorescent staining of human cell line BJ shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43930/1742_E9_18_cr5804930fbb88d_selected.jpg
(Immunofluorescent staining of human cell line BJ shows localization to endoplasmic reticulum.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/images/43930/1742_E9_18_cr5804930fbb88d_selected.jpg
Figure 2 RNA cell line category: Cell line enhanced (BJ, fHDF/TERT166, HSkMC, U-138 MG)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113083-LOX
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000113083-LOX
Specifications
- Host Species
- Rabbit
- Type
- Rabbit IgG
- Specificity
- Human, Mouse and Rat LOX
- Species Reactivity
- Human, Mouse, Rat
- Clone
- R09-6N5
- Applications
- WB, IHC-P, ICC, IF, IP, FC
- Related Disease
- Aortic Aneurysm, Familial Thoracic 10
Product Property
- Clonality
- Monoclonal
- Aggregation
- < 5%
- Format
- Liquid
- Buffer
- PBS (pH 7.4), 150 mM NaCl and 50% glycerol
- Preservative
- 0.02% sodium azide
- Storage
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- WB: 1/500-1/1000
IHC: 1/50-1/100
IF: 1/50-1/200
IP: 1/20
FC: 1/50-1/100
Target
- Alternative Names
- AAT10
- Gene ID
- 4015
- Long Name
- Lysyl oxidase
- Cellular Localization
- Secreted
- Post Translation Modifications
- Sulfated at Tyr-187 and also at either Tyr-183 or Tyr-184 which enhances binding to collagen. (P28300-LYOX_HUMAN)
Glycosylation at Asn81, Thr89, Asn97, Thr113, Thr120, Ser130, Thr131, Ser132, Asn144, and Thr413 (NX_P28300 [NX_P28300-1])
Modification sites at PhosphoSitePlus (P28300)
Glycosylation from GlyConnect LYOX_HUMAN (816)
Glycosylation from GlyGen (P28300) 14 sites, 15 N-linked glycans (4 sites), 3 O-linked glycans (9 sites)
- Protein Refseq
- NP_001304002.1
- Function
- Responsible for the post-translational oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin (PubMed:26838787).
Regulator of Ras expression.
May play a role in tumor suppression.
Plays a role in the aortic wall architecture.
Recommended Products
Isotype Control
Recommended Dilution Buffer
Secondary Antibody
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IHC Kit and Antibody Products: Precision Tools for Immunohistochemistry
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-629 | Recombinant Anti-human LOX Antibody | ELISA, WB, IF, FuncS | IgG |
| MHH-629 | Recombinant Human Anti-human LOX Antibody | FC, RIA, Biosensors, FuncS | IgG |
| MRO-0936-CN | Recombinant Rabbit Anti-LOX Monoclonal Antibody (JU30-23) | WB, IF, IHC, FC | Rabbit IgG |
| VS3-XY1015 | Mouse Anti-LOX Recombinant Antibody (clone 624CT23.7.3) | WB | Mouse IgG2b |
| VS3-XY1016 | Mouse Anti-LOX Recombinant Antibody (clone 2G5) | WB, IP, IF, IHC | Mouse IgG1 |
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