Anti-MUC4 (clone W24V236) Recombinant Antibody Coupled Liposome (VS-1024-FY233)
CAT#: VS-1024-FY233
Anti-MUC4 antibody conjugated liposomes show significant potential in pancreatic cancer research by enhancing targeted drug delivery to tumor cells that express MUC4, a tumor-associated antigen. This targeted approach could improve therapeutic efficacy while minimizing off-target effects, thereby increasing the safety profile of cancer treatments. Additionally, these liposomes can be engineered to deliver various therapeutic agents, including chemotherapeutics or RNA-based therapies, enabling a multifunctional treatment strategy. Furthermore, the use of such liposomes may facilitate the monitoring of treatment responses through imaging techniques, paving the way for more personalized cancer therapies.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in goblet cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5895/ihc_selected.jpg
Normal Tissue
Figure 2 IHC staining of human colon
Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/13536/31075_A_7_3_selected.jpg
Normal Tissue
Figure 3 Colon
Glandular cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5895/17409_A_8_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5895/17409_A_8_5.jpg
Normal Tissue
Figure 5 Testis
Cells in seminiferous ducts Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/5895/17409_A_6_6.jpg
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More Infomation
Specifications
- Potential Clinical Applications
- Pancreatic cancer
Product Composition
- Clone
- W24V236
- Antibody Type
- IgG1
- Antibody Host
- Mouse
- Antibody Reactivity
- Human
- Antibody Description
- This antibody is a recombinant mouse monoclonal that has been specifically engineered to target MUC4. It plays a crucial role in research and diagnostic applications by binding to the MUC4 protein, which is often associated with various cancers. With its high specificity and affinity, this antibody assists scientists in studying the functions and implications of MUC4 in cellular processes.
Product Property
- Storage
- See in the COA
- Storage Shelf Time
- See in the COA
Target Information
- Target
- MUC4
- Introduction
- The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.
- Alternative Names
- Mucin 4, Cell Surface Associated; Pancreatic Adenocarcinoma Mucin; Mucin 4, Tracheobronchial; Ascites Sialoglycoprotein; Tracheobronchial Mucin; Testis Mucin
- Full Name
- Mucin 4, Cell Surface Associated
- Gene ID
- 4585
- UniProt ID
- Q99102
- Cellular Localization
- Cell membrane, Membrane, Secreted
- Positive Control
- The positive control samples for this antibody include Appendix.
- Post Translation Modifications
- Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.
- Protein Refseq
- NP_001309397.1; NP_004523.3; NP_060876.5; NP_612154.2
- Function
- These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978).
Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor.
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Datasheet
MSDS
COA
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See other products for "MUC4"
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-3164z | Mouse Anti-MUC4 Recombinant Antibody (clone 6A10) | WB, IP, IF, IHC | Mouse IgG1, κ |
| MOB-1262CT | Recombinant Mouse anti-Human MUC4 Monoclonal antibody (5B12) | ELISA, FC, IHC-P, WB | |
| MRO-1043-CN | Recombinant Rabbit Anti-MUC4 Monoclonal Antibody (JM19-36) | WB, IHC, FC | Rabbit IgG |
| MOB-0114F | Mouse Anti-MUC4 Recombinant Antibody (MOB-0114F) | IHC-P, IF | Mouse IgG |
| VS3-FY984 | Recombinant Mouse Anti-MUC4 Antibody (clone 4G9-2D7-7A3) | IHC-P | Mouse IgG2b |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-2323 | Hi-Affi™ Recombinant Rabbit Anti-MUC4 Monoclonal Antibody (DS2323AB) | IHC-P | IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1396 | Anti-MUC4 Immunohistochemistry Kit | IHC | |
| VS-0525-XY4583 | Anti-Human MUC4 Immunohistochemistry Kit | IHC |
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