Anti-MUC4 (clone W24V236) Recombinant Antibody Coupled Liposome (VS-1024-FY233) (CAT#: VS-1024-FY233)

• Potential Clinical Applications
• Pancreatic cancer

• Clone
• W24V236

• Antibody Type
• IgG1

• Antibody Host
• Mouse

• Antibody Reactivity
• Human

• Antibody Description
• This antibody is a recombinant mouse monoclonal that has been specifically engineered to target MUC4. It plays a crucial role in research and diagnostic applications by binding to the MUC4 protein, which is often associated with various cancers. With its high specificity and affinity, this antibody assists scientists in studying the functions and implications of MUC4 in cellular processes.

• Storage
• See in the COA

• Storage Shelf Time
• See in the COA

• Target
• MUC4

• Introduction
• The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.

• Alternative Names
• Mucin 4, Cell Surface Associated; Pancreatic Adenocarcinoma Mucin; Mucin 4, Tracheobronchial; Ascites Sialoglycoprotein; Tracheobronchial Mucin; Testis Mucin

• Full Name
• Mucin 4, Cell Surface Associated

• Gene ID
• 4585

• UniProt ID
• Q99102

• Cellular Localization
• Cell membrane, Membrane, Secreted

• Positive Control
• The positive control samples for this antibody include Appendix.

• Post Translation Modifications
• Proteolytically cleaved into 2 chains, mucin-4 alpha chain and mucin-4 beta chain.

• Protein Refseq
• NP_001309397.1; NP_004523.3; NP_060876.5; NP_612154.2

• Function
• These glycoproteins play important roles in the protection of the epithelium and are implicated in epithelial renewal and differentiation (PubMed:10880978).
  Regulates cellular behavior through both anti-adhesive effects on cell-cell and cell-extracellular matrix interactions and its ability to act as an intramembrane ligand for ERBB2. Plays an important role in proliferation and differentiation of epithelial cells by inducing specific phosphorylation of ERBB2. In polarized epithelial cells, segregates ERBB2 and other ERBB receptors and prevents ERBB2 from acting as a coreceptor.

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