AbPlus™ Anti-PHGDH Magnetic Beads (VS-0724-YC907)
CAT#: VS-0724-YC907
The AbPlus Anti-PHGDH Magnetic Beads (VS-0724-YC907) is an innovative affinity resin which is bound with anti-PHGDH specific antibody. The beads were designed for small-scale affinity purification and immunoprecipitation (IP) of PHGDH protein under native and denaturing conditions.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21241/if_selected.jpg
Subcellular Location
Figure 2 IF staining of human cell line MCF7
Immunofluorescent staining of human cell line MCF7 shows localization to nucleoplasm, plasma membrane & cytosol.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/24031/if_selected.jpg
Normal Tissue
Figure 3 IHC staining of human cervix, uterine
Immunohistochemical staining of human cervix, uterine shows cytoplasmic and nuclear positivity in squamous epithelia.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/21241/158736_B_7_3_selected.jpg
Normal Tissue
Figure 4 Parathyroid gland.
High expression in parathyroid gland
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/3681/10161_A_1_8_val_selected.jpg
Normal Tissue
Figure 5 IHC staining of human skin
Immunohistochemical staining of human skin shows strong cytoplasmic and nuclear positivity in epidermal cells.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/ihc_selected.jpg
Normal Tissue
Figure 6 Salivary gland
Glandular cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/152505_B_3_1.jpg
Normal Tissue
Figure 7 Liver
Cholangiocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Hepatocytes Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/152505_A_8_4.jpg
Normal Tissue
Figure 8 Kidney
Cells in glomeruli Staining: Medium Intensity: Strong Quantity: <25% Location: Cytoplasmic/ membranous Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/152505_A_8_5.jpg
Normal Tissue
Figure 9 Lymph node
Germinal center cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Non-germinal center cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/152505_A_7_8.jpg
Normal Tissue
Figure 10 Cerebral cortex
Endothelial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Glial cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuropil Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/68216/152505_B_9_5.jpg
RNA Expression
Figure 11 RNA cell line category: Cell line enhanced (SK-MEL-30)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000092621-PHGDH
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Specifications
- Applications
- Immunoprecipitation, Protein Purification
- Matrix
- Magnetic bead
- Bead Ligand
- Anti-PHGDH specific antibody
- Target
- PHGDH
- Immunogen
- Synthetic peptide corresponding to the center region of the human PHGDH.
- Target Species
- Human, Pongo abelii, Pig
- Bead Capacity
- 40 mg/mL
- Bead size
- 25 μm
- Format
- Suspension
- Concentration
- 2 mg/mL
- Buffer
- PBS, pH 7.4
- Preservative
- 0.1% Sodium azide
- Storage
- Stored at 4°C, and is stable for up to 2 years. Do not centrifuge, dry or freeze the magnetic beads.
Applications
- Application Notes
- The beads are in suspension and will settle upon storage. Prior to use, mix the vial gently (do not vortex) to ensure delivery of proper bead volume.
Target
- Introduction
- This gene encodes the enzyme which is involved in the early steps of L-serine synthesis in animal cells. L-serine is required for D-serine and other amino acid synthesis. The enzyme requires NAD/NADH as a cofactor and forms homotetramers for activity. Mutations in this gene have been found in a family with congenital microcephaly, psychomotor retardation and other symptoms. Multiple alternatively spliced transcript variants have been found, however the full-length nature of most are not known. [provided by RefSeq, Aug 2011]
- Alternative Names
- Phosphoglycerate Dehydrogenase; 2-Oxoglutarate Reductase; Malate Dehydrogenase; EC 1.1.1.95; 3-PGDH; Epididymis Secretory Protein Li 113; D-3-Phosphoglycerate Dehydrogenase; 3-Phosphoglycerate Dehydrogenase; EC 1.1.1.399; EC 1.1.1.37; HEL-S-113; EC 1.1.1;
- Gene ID
- 26227
- UniProt ID
- O43175
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Datasheet
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COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "PHGDH"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-2201z | Mouse Anti-PHGDH Recombinant Antibody (clone 29H3) | WB, ELISA, IF, IHC, IP | Mouse IgG1, κ |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0724-YC510 | AbPlus™ Anti-PHGDH Magnetic Beads (VS-0724-YC510) | IP, Protein Purification |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0325-XY1642 | Anti-PHGDH Immunohistochemistry Kit | IHC | |
| VS-0525-XY5371 | Anti-Mouse PHGDH Immunohistochemistry Kit | IHC | |
| VS-0525-XY5370 | Anti-Human PHGDH Immunohistochemistry Kit | IHC |
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