Mouse Anti-PSMC2 Recombinant Antibody (VS3-FY2846) (CAT#: VS3-FY2846)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• Human and Mouse PSMC2

• Species Reactivity
• Human, Mouse

• Applications
• Western Blot

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 48.6 kDa.

• Related Disease
• Retinal Melanoma and Cystic Fibrosis

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000

• Alternative Names
• S7; MSS1; RPT1; Nbla10058

• Gene ID
• 5701

• UniProt ID
• P35998

• Sequence Similarities
• Belongs to the AAA ATPase family.

• Cellular Localization
• Cytoplasm

• Post Translation Modifications
• Monoubiquitinated by RNF181. (P35998-PRS7_HUMAN)
  Phosphorylated (PubMed:28539385).
  Dephosphorylated by UBLCP1 which impairs PSMC2 ATPase activity and disrupts 26S proteasome assembly (PubMed:28539385).
  (P35998-PRS7_HUMAN)
  Ubiquitination at Lys146, Lys34, Lys181, Lys46, Lys57, Lys210, Lys84, Lys222, Lys100, Lys110, Lys248, Lys116, Lys120, Lys267, Lys268, Lys340, Lys402, Lys407, Lys415, and Lys422 (NX_P35998 [NX_P35998-1])
  Modification sites at PhosphoSitePlus (P35998)
  Glycosylation from GlyGen (P35998) 1 site, 1 O-linked glycan (1 site)

• Protein Refseq
• NP_002794.1

• Function
• Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.
  This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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