Mouse Anti-Tn Antigen Recombinant Antibody (clone MLS128) (CAT#: HPAB-0319CQ)
This product is a recombinant mouse antibody that can bind to Tn Antigen with high affinity.
We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.
Figure 1 Specificity of VVL and antibodies on large trimer amino acid glycopeptide library, printed on microarray slides.
The library was divided into five groups according to the position of glycosylated (GalNAc) serine (S*) and threonine (T*) in relation to other amino acids (X). VVL, scFv sH1 and G2-D11, mouse monoclonal GOD3-2C4 and MLS128 antibodies were tested in all combinations. Each dot represents a unique sub-library member. Median signals for each group of combinations are marked with a blue line and a red circle is highlighting amino acids (X) affecting binding of the reagents. (A) Group 1 (XT*T*). (B) Group 2 (T*T*X). (C) Group 3 (XT*S*). (D) Group 4 (S*T*X). (E) Group 5a (GT*X3, PT*X3, WT*X3, IT*X3, LT*X3, MT*X3, FT*X3, YT*X3 and VT*X3), where G2-D11 bound to FT*R, WT*K, YT*W and YT*A, and GOD3-2C4 bound to VT*N, VT*M, VT*W, WT*C, WT*D, WT*E, WT*I, WT*M, WT*N, YT*F, YT*M and YT*R. (F) Group 5b (RT*X3, HT*X3, KT*X3, DT*X3, ET*X3, ST*X3, TT*X3, NT*X3 and QT*X3), where GOD3-2C4 bound to HT*R. This figure is available in black and white in print and in colour at Glycobiology online.
Persson, N., Stuhr-Hansen, N., Risinger, C., Mereiter, S., Polónia, A., Polom, K., ... & Danielsson, L. (2017). Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells. Glycobiology, 27(7), 635-645.
Figure 2 Specificity evaluation of Tn-binding antibodies on glycopeptide microarray.
Glycopeptides were printed on a microarray chip. MLS128 were titrated from 20 μg/mL in a series of 10, 5, 1, 0.5, 0.1 and 0.05 μg/mL.
Persson, N., Stuhr-Hansen, N., Risinger, C., Mereiter, S., Polónia, A., Polom, K., ... & Danielsson, L. (2017). Epitope mapping of a new anti-Tn antibody detecting gastric cancer cells. Glycobiology, 27(7), 635-645.
Specifications
- Host Species
- Mouse
- Type
- Mouse IgG3
- Specificity
- Tn Antigen
- Clone
- MLS128
- Applications
- WB, IHC, DB, FC, Inhib
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Target
- Alternative Names
- Tn Antigen; GalNAc-O-Ser/Thr
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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CAT | Product Name | Application | Type |
---|---|---|---|
MOB-980 | Recombinant Anti-Tn antigen Antibody | ELISA, WB, FuncS | IgG |
MHH-980 | Recombinant Human Anti-Tn antigen Antibody | IF, WB, FuncS | IgG |
MOB-030CQ | Mouse Anti-Tn Antigen Recombinant Antibody (clone YC145) | WB, IF, IHC | Mouse IgM, κ |
FAMAB-0311JF | Mouse Anti-Tn antigen Recombinant Antibody (clone 83D4) | IB, IF, ELISA, FuncS | Mouse IgM, κ |
FAMAB-1419CQ | Human Anti-Tn antigen Recombinant Antibody (clone 237) | WB, ELISA | Human IgG1 |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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