Human Anti-Toxin Recombinant Antibody (clone RU1) (CAT#: HPAB-S0145-YC)
Antibody clone RU1 recognizes the Cn2 and Cll1 toxins, which derived from clone C1. RU1 showed a good capacity to neutralize the Cn2 toxin and whole venom of the scorpion Centruroides noxius.
Specific Inquiry
Figure 1 Competition binding assays of scFvs LR and RU1 with the Cn2 toxin.
These results clearly indicated that the scFvs recognized different sites on the toxin. This is significant because the toxins were neutralized through the binding of the scFvs to non-overlapping sites, which improved their efficiency as an antivenom.
Riaño-Umbarila, L., Ledezma-Candanoza, L. M., Serrano-Posada, H., Fernández-Taboada, G., Olamendi-Portugal, T., Rojas-Trejo, S., ... & Becerril, B. (2016). Optimal neutralization of Centruroides noxius venom is understood through a structural complex between two antibody fragments and the Cn2 toxin. Journal of Biological Chemistry, 291(4), 1619-1630.
Specifications
- Host Species
- Human
- Type
- Human IgG
- Specificity
- Centruroides noxius
- Species Reactivity
- C. noxius
- Clone
- RU1
- Applications
- Neut, FuncS
Product Property
- Purity
- >95% as determined by SDS-PAGE and HPLC analysis
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Recombinant Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-0934-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0934-FY) | ELISA, Neut, WB | Llama VHH |
| HPAB-0935-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0935-FY) | ELISA, Neut, WB | Llama VHH |
| HPAB-0936-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0936-FY) | ELISA, Neut, WB | Llama VHH |
| HPAB-0937-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0937-FY) | ELISA, Neut | Llama VHH |
| HPAB-S0146-YC | Human Anti-Toxin Recombinant Antibody (clone LR) | Neut, FuncS | Human IgG |
Fab Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0145-YC-F(E) | Human Anti-Toxin Recombinant Antibody (clone RU1); Fab Fragment | Neut, FuncS | Human Fab |
| HPAB-S0146-YC-F(E) | Human Anti-Toxin Recombinant Antibody (clone LR); Fab Fragment | Neut, FuncS | Human Fab |
scFv Fragment Antibody
| CAT | Product Name | Application | Type |
|---|---|---|---|
| HPAB-S0145-YC-S(P) | Human Anti-Toxin Recombinant Antibody (clone RU1); scFv Fragment | Neut, FuncS | Human scFv |
| HPAB-S0146-YC-S(P) | Human Anti-Toxin Recombinant Antibody (clone LR); scFv Fragment | Neut, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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