Clone LR was obtained after three cycles of directed evolution of the parental clone 3F and incorporating a V101F mutation into one of the derived variant clones (9004G). This antibody clone recognizes and neutralizes the main toxins from the venoms of the C. noxius and Centruroides suffusus suffusus scorpions (Cn2 and Css2, respectively), with affinities in the picomolar range, and removes any poisoning symptoms. In neutralization tests using fresh whole venom in mice, clone LR was capable of inhibiting nearly all symptoms caused by the C. suffusus suffusus venom.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Download resources about recombinant antibody development and antibody engineering to boost your research.
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-0934-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0934-FY) | ELISA, Neut, WB | Llama VHH |
HPAB-0935-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0935-FY) | ELISA, Neut, WB | Llama VHH |
HPAB-0936-FY | Llama Anti-Toxin Recombinant Antibody; VHH Fragment (HPAB-0936-FY) | ELISA, Neut, WB | Llama VHH |
HPAB-S0145-YC | Human Anti-Toxin Recombinant Antibody (clone RU1) | Neut, FuncS | Human IgG |
HPAB-S0146-YC | Human Anti-Toxin Recombinant Antibody (clone LR) | Neut, FuncS | Human IgG |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-S0145-YC-F(E) | Human Anti-Toxin Recombinant Antibody (clone RU1); Fab Fragment | Neut, FuncS | Human Fab |
HPAB-S0146-YC-F(E) | Human Anti-Toxin Recombinant Antibody (clone LR); Fab Fragment | Neut, FuncS | Human Fab |
CAT | Product Name | Application | Type |
---|---|---|---|
HPAB-S0145-YC-S(P) | Human Anti-Toxin Recombinant Antibody (clone RU1); scFv Fragment | Neut, FuncS | Human scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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