Human Anti-GPRV scFv-Fc Chimera (VS-0125-FY86)
CAT#: VS-0125-FY86
Recombinant human antibody molecules targeting the glycoprotein antigen of rabies virus (GPRV) were constructed in the form of single-chain variable fragments (scFv). In a standard in vivo neutralization assay, we found that two scFv-Fc fusion proteins were able to effectively neutralize the PV11 virus strain. This was validated through intracranial inoculation experiments in mice after co-incubating the virus with the scFv-Fc molecules. These anti-GPRV scFv-Fc molecules demonstrate great potential as alternatives to existing human rabies immune globulin (HRIG) in post-exposure prophylaxis.
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Species Reactivity
- Rabies virus (RABV)
- Applications
- Neutralization
- Related Disease
- Rabies virus (RABV) infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Buffer
- PBS
- Preservative
- No preservatives
- Stabilizer
- No Stabilizers
- Sterility
- 0.2 μM filtered
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- The anti-GPRV scFv-Fc molecule, which can effectively neutralize the PV11 virus strain, shows great potential as an alternative to existing human rabies immune globulin (HRIG) in post-exposure prophylactic treatment.
Target
- Alternative Names
- Glycoprotein antigen of the rabies virus, RABV-G, GPRV
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "GPRV"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162WJ | Human Anti-GPRV Recombinant Antibody (clone IV-62) | ELISA, WB, Neut | Human IgG1 |
| FAMAB-0163WJ | Human Anti-GPRV Recombinant Antibody (clone IV-67) | ELISA, WB, Neut | Human IgG1 |
| FAMAB-0164WJ | Human Anti-GPRV Recombinant Antibody (clone III-20) | ELISA, WB, Neut | Human IgG1 |
| FAMAB-0165WJ | Human Anti-GPRV Recombinant Antibody (clone III-30) | ELISA, WB, Neut | Human IgG1 |
| FAMAB-0166WJ | Human Anti-GPRV Recombinant Antibody (clone III-35) | ELISA, WB, Neut | Human IgG1 |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162WJ-S(P) | Human Anti-GPRV Recombinant Antibody (clone IV-62); scFv Fragment | ELISA, WB, Neut | Human scFv |
| FAMAB-0163WJ-S(P) | Human Anti-GPRV Recombinant Antibody (clone IV-67); scFv Fragment | ELISA, WB, Neut | Human scFv |
| FAMAB-0164WJ-S(P) | Human Anti-GPRV Recombinant Antibody (clone III-20); scFv Fragment | ELISA, WB, Neut | Human scFv |
| FAMAB-0165WJ-S(P) | Human Anti-GPRV Recombinant Antibody (clone III-30); scFv Fragment | ELISA, WB, Neut | Human scFv |
| FAMAB-0166WJ-S(P) | Human Anti-GPRV Recombinant Antibody (clone III-35); scFv Fragment | ELISA, WB, Neut | Human scFv |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| FAMAB-0162WJ-F(E) | Human Anti-GPRV Recombinant Antibody (clone IV-62); Fab Fragment | ELISA, WB, Neut | Human Fab |
| FAMAB-0163WJ-F(E) | Human Anti-GPRV Recombinant Antibody (clone IV-67); Fab Fragment | ELISA, WB, Neut | Human Fab |
| FAMAB-0164WJ-F(E) | Human Anti-GPRV Recombinant Antibody (clone III-20); Fab Fragment | ELISA, WB, Neut | Human Fab |
| FAMAB-0165WJ-F(E) | Human Anti-GPRV Recombinant Antibody (clone III-30); Fab Fragment | ELISA, WB, Neut | Human Fab |
| FAMAB-0166WJ-F(E) | Human Anti-GPRV Recombinant Antibody (clone III-35); Fab Fragment | ELISA, WB, Neut | Human Fab |
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