Human Anti-HIV-1 V3 (clone A7) scFv-Fc Chimera (CAT#: VS-0325-FY128)
The Anti-HIV-1 V3 scFv-Fc Antibody is a novel fusion protein designed for potential therapeutic and prophylactic applications against HIV-1 infection. This antibody combines a high-affinity single-chain variable fragment (scFv) derived from an HIV-1 long-term non-progressor (LTNP) with an IgG1 Fc domain. The scFv component specifically targets the V3 loop of the HIV-1 envelope glycoprotein gp120, a region critical for viral entry. The Fc domain may facilitate immune-mediated effector functions, such as antibody-dependent cell-mediated cytotoxicity (ADCC).
Specific Inquiry
Specifications
- Host Species
- Human
- Type
- Human IgG1, scFv-Fc
- Specificity
- HIV-1 V3
- Species Reactivity
- Human immunodeficiency virus 1 (HIV-1)
- Clone
- A7
- Applications
- Neutralization, ADCC
- Related Disease
- HIV-1 infection
Product Property
- Purity
- >95% as determined by SDS-PAGE
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
- Shipping
- Ice packs
Applications
- Application Notes
- Neutralization: The scFv domain binds to the V3 loop of gp120, potentially blocking its interaction with the co-receptor and inhibiting viral entry.
Target
- Alternative Names
- V3 loop, HIV-1 V3
- Long Name
- HIV-1 gp120 V3 loop
- Function
- HIV-1 V3 loop is a variable region of the HIV-1 envelope glycoprotein gp120, crucial for co-receptor binding and viral entry. It is a target for neutralizing antibodies and contributes to viral diversity.
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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IgG Antibody Products
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ScFv Antibody Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-493 | Recombinant Anti-HIV-1 V3 Antibody | ELISA, WB, IF, FuncS | IgG |
| MHH-493 | Recombinant Human Anti-HIV-1 V3 Antibody | ELISA, WB, IF, FuncS | IgG |
| PABL-569 | Human Anti-HIV-1 V3 Recombinant Antibody (PABL-569) | WB, ELISA, Neut, FuncS | Human IgG1, λ |
| PABL-570 | Human Anti-HIV-1 V3 Recombinant Antibody (clone 3074) | WB, ELISA, Neut, FuncS | Human IgG1,λ |
| PABL-571 | Human Anti-HIV-1 V3 Recombinant Antibody (clone 1006-15D) | WB, ELISA, FuncS | Human IgG1,λ |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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