Recombinant Human Anti-SCN3A Soluble TCR (SB7) (C-Cys)
CAT#: VS-0622-YF5049
Human TCR (SB7) recognizes SCN3A peptide (ALVGAIPSI) in the context of HLA-A2. Soluble TCR is expressed with C-terminal Cys strategy (TRAV-TRAC partial-Cys, TRBV-TRBC partial-Cys). Depending the C-terminal Cys, two chains form heterodimer. Please note that the activity is not guaranteed.
Gene Expression
Normal Tissue
Figure 1 IHC staining of human caudate
Immunohistochemical staining of human caudate shows strong cytoplasmic positivity in neurons.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/ihc_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Neuronal cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_9_5.jpg
Normal Tissue
Figure 3 Cerebellum
Cells in granular layer Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous Cells in molecular layer Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous Purkinje cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_B_7_8.jpg
Normal Tissue
Figure 4 Colon
Glandular cells Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous Peripheral nerve/ganglion Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_3.jpg
Normal Tissue
Figure 5 Liver
Cholangiocytes Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_4.jpg
Normal Tissue
Figure 6 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_8_5.jpg
Normal Tissue
Figure 7 Testis
Leydig cells Staining: Low Intensity: Weak Quantity: 75%-25% Pachytene spermatocytes Staining: Low Intensity: Weak Quantity:>75% Preleptotene spermatocytes Staining: Medium Intensity: Moderate Quantity:>75% Spermatogonia cells Staining: Medium Intensity: Moderate
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/35396/73252_A_4_6.jpg
RNA Expression
Figure 8 RNA cell line category: Cell line enhanced (JURKAT, Karpas-707, MOLT-4, RPTEC TERT1, SH-SY5Y)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000153253-SCN3A
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Specifications
- Host Species
- Human
- Target
- SCN3A
- Species Reactivity
- Human
- Epitope
- ALVGAIPSI
- MHC
- HLA-A2
- Clone
- SB7
- Type
- Soluble TCR (C-Cys)
- TCR Expression Strategy
- C-Cys strategy: the alpha and beta chain (without transmembrane and cytosolic region) can form heterodimer based on C-terminal Cys. The soluble TCR contains variable regions and partial constant regions.
Target
- Alternative Names
- Sodium Voltage-Gated Channel Alpha Subunit 3; Sodium Channel, Voltage-Gated, Type III, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type III Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.3; Sodium Channel Protein Brain III Subunit Alpha; Sodium Channel Protein Type III Subunit Alpha; Voltage-Gated Sodium Channel Subtype III
- Gene ID
- 6328
- UniProt ID
- Q9NY46
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| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0625-FY138 | Mouse Anti-SCN3A Recombinant Antibody (clone 2506W0033) | ELISA | Mouse IgG |
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