Recombinant Anti-ABCB4 Vesicular Antibody, EV Displayed (VS-0425-YC371)
CAT#: VS-0425-YC371
The Recombinant Anti-ABCB4 Vesicular Antibody, EV Displayed (VS-0425-YC371) is an antibody-displaying extracellular vesicle (Ab-EV). The product combines the benefits of both extracellular vesicle (EV) and antibody (Ab) which can guide the decorated EVs to ABCB4-expressed cells or tissues. The ABCB4 is an ABC transporter subfamily member that is implicated in phospholipid transport, involved in drug resistance and antigen presentation.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line U-2 OS
Immunofluorescent staining of human cell line U-2 OS shows localization to nucleoplasm, plasma membrane & focal adhesion sites.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49395/if_selected.jpg
Normal Tissue
Figure 2 IHC staining of human liver
Immunohistochemical staining of human liver shows strong positivity in bile canaliculi.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/49395/124384_A_7_4_selected.jpg
Normal Tissue
Figure 3 High expression in liver
Hepatocytes Staining: High Intensity: Strong Quantity: 75%-25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/53288/166934_A_8_4.jpg
RNA Expression
Figure 4 RNA cell line category: Group enriched (SH-SY5Y, WM-115)
Cell lines ordered by descending RNA expression order.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000005471-ABCB4
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Recombinant Antibody
- Application
- ELISA, FC, Cell-uptake
- Product Type
- Ab-Fc-EVs
- Antibody Quantification (Ab/EV)
- ~100 Ab/EV
- Target
- ABCB4
- Host Animal
- Human
- Antibody Isotype
- IgG
- Species Reactivity
- Human
- Expression Cell
- Mammalian cell
Engineered EVs
- EV-sorting domain
- CD63
- Fc-binding domain
- z domain
- EV Size
- 30~150 nm
- Producing Cell
- HEK293F
- Isolation Method
- Gradient centrifugation
- Purification
- qEV size exclusion chromatography
- Binding Affinity
- Kd = 0.85 µg/mL
- Concentration
- 1 x 10¹⁰
- Size
- 1 mL
- Buffer
- PBS
- Storage
- Store at -80°C for 12 months
Target
- Full Name
- ATP binding cassette subfamily B member 4
- Biological Process
- Lipid transport, Transport
- Molecular Function
- Translocase
- Cellular Localization
- Nucleoplasm, Plasma membrane, Focal adhesion sites, Cytosol
- Introduction
- The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a full transporter and member of the p-glycoprotein family of membrane proteins with phosphatidylcholine as its substrate. The function of this protein has not yet been determined; however, it may involve transport of phospholipids from liver hepatocytes into bile. Alternative splicing of this gene results in several products of undetermined function.
- Alternative Names
- GBD1, MDR2, MDR3, PFIC-3, PGY3
- Gene ID
- 5244
- UniProt ID
- P21439
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Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
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See other products for "ABCB4"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0520MZ | Mouse Anti-ABCB4 Recombinant Antibody (clone Q4JJ-37) | FC, ICC, IHC-Fr, WB | Mouse IgG2b |
| VS3-QX3 | Mouse Anti-ABCB4 Recombinant Antibody (clone 1808CT346.21.23) | WB | Mouse IgG1, κ |
| VS3-FY2617 | Mouse Anti-ABCB4 Recombinant Antibody (VS3-FY2617) | WB | Mouse IgG |
| VS-0824-YJ43 | Human Anti-ABCB4 Recombinant Antibody (VS-0824-YJ43) | ELISA | Human IgG1 kappa |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| VS-0525-XY19 | Anti-ABCB4 Immunohistochemistry Kit | IHC |
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