Mouse Anti-ABCB4 Recombinant Antibody (VS3-FY2617) (CAT#: VS3-FY2617)

• Host Species
• Mouse

• Type
• Mouse IgG

• Specificity
• ATP binding cassette subfamily B member 4 of human, mouse and rat origins

• Species Reactivity
• Human, Mouse, Rat

• Applications
• WB

• Conjugate
• Unconjugated, FITC

• MW
• The molecular weight of the target protein is approximately 141.5 kDa.

• Related Disease
• Cholestasis, Progressive Familial Intrahepatic, 3 and Gallbladder Disease 1

• Clonality
• Monoclonal Antibody

• Format
• Liquid

• Concentration
• Please refer to the vial label for the specific concentration.

• Storage
• Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.

• Application Notes
• Western Blot: 1/500-1/2000

• Alternative Names
• ATP Binding Cassette Subfamily B Member 4; ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 4; ATP-Binding Cassette Sub-Family B Member 4; Multidrug Resistance Protein 3; P-Glycoprotein 3; EC 3.6.3.44; MDR3; PGY3; P-Glycoprotein-3/Multiple Drug Resistance-3; Phosphatidylcholine Translocator ABCB4

• Gene ID
• 5244

• UniProt ID
• P21439

• Sequence Similarities
• Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily.

• Cellular Localization
• Cell membrane; Multi-pass membrane protein
  Apical cell membrane; Multi-pass membrane protein
  Membrane raft
  Cytoplasm

• Post Translation Modifications
• Phosphorylated.
  Phosphorylation on Thr-34 is required for PC efflux activity.
  Phosphorylation occurs on serine and threonine residues in a protein kinase A- or C-dependent manner.
  May be phosphorylated on Thr-44 and Ser-49.
  Glycosylated.
  Glycosylation at Asn91 and Asn97
  Modification sites at PhosphoSitePlus
  Glycosylation from GlyGen 2 sites

• Protein Refseq
• XP_011514610.4; XP_011514611.4; XP_047276431.1; XP_047276432.1; XP_047276433.1

• Function
• Functions as a floppase that translocates specifically phosphatidylcholine (PC) from the inner to the outer leaflet of the canalicular membrane bilayer into the canaliculi of hepatocytes.
  Translocation of PC makes the biliary phospholipids available for extraction into the canaliculi lumen by bile salt mixed micelles and therefore protects the biliary tree from the detergent activity of bile salts.

Secondary Antibody

• 2ND-040CQ
• Goat Anti-Mouse IgG (H&L) Antibody

Isotype Control

• MRO-A1591-YJ
• Mouse IgG Isotype control, Polyclonal

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