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AKR1C4
Anti-AKR1C4 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, ELISA, IF, IHC
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- Recombinant Mouse Anti-Human AKR1C4 Antibody (MOB-1140MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: ICC/IF, WB
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the bioreduction of chlordecone, a toxic organochlorine pesticide, to chlordecone alcohol in liver. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (HDLM-2, OE19)
Interaction
Monomer.
Molecular function
Oxidoreductase
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