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ALX1
Anti-ALX1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The specific function of this gene has yet to be determined in humans; however, in rodents, it is necessary for survival of the forebrain mesenchyme and may also be involved in development of the cervix. Mutations in the mouse gene lead to neural tube defects such as acrania and meroanencephaly.
Protein class
Disease related genes, Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enriched (Melanocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HAP1, HEK93, HUVEC TERT2, SK-MEL-30, THP-1, WM-115)
Interaction
Binds DNA as a homodimer; required for transcriptional activation (PubMed:9753625). Interacts (via homeobox domain) with EP300; acetylates ALX1 and stimulates its transcriptional activity.
Molecular function
Activator, Developmental protein, DNA-binding, Repressor
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