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AMBP
Anti-AMBP Recombinant Antibody Products
- AbPlus™ Anti-AMBP Magnetic Beads (VS-0724-YC1266) (VS-0724-YC1266)
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- Target: AMBP
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a complex glycoprotein secreted in plasma. The precursor is proteolytically processed into distinct functioning proteins: alpha-1-microglobulin, which belongs to the superfamily of lipocalin transport proteins and may play a role in the regulation of inflammatory processes, and bikunin, which is a urinary trypsin inhibitor belonging to the superfamily of Kunitz-type protease inhibitors and plays an important role in many physiological and pathological processes. This gene is located on chromosome 9 in a cluster of lipocalin genes. [provided by RefSeq, Jul 2008]
Protein class
Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enriched (Hepatocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
[Alpha-1-microglobulin]: Monomer (PubMed:22512701, PubMed:9183005). Homodimer (PubMed:9183005). In plasma, it occurs as a monomer or dimer and in covalently-linked complexes with immunoglobulin A (IgA), ALB/albumin and F2/prothrombin (PubMed:9183005). Chromophore-bound alpha-1-microglobulin interacts with the constant region of immunoglobulin A (PubMed:9183005). Chromophore-bound alpha-1-microglobulin interacts with ALB with molar ratio 2:1 and 1:1; this interaction does not prevent fatty acid binding to ALB (PubMed:9183005). Interacts with F2/prothrombin (via N-terminus) with molar ratio 2:1 and 1:1; this interaction does not prevent the activation of prothrombin to thrombin (PubMed:9183005). Interacts with NDUFAB1, a subunit of mitochondrial complex I (PubMed:23157686). Interacts with FN1 (By similarity). [Inter-alpha-trypsin inhibitor light chain]: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (HC) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of ITIH1/HC1, ITIH2/HC2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of ITIH3/HC3 and bikunin (PubMed:2476436, PubMed:16873769). Interacts with TNFAIP6 (via Link domain) (PubMed:15917224). [Trypstatin]: Monomer. Also occurs as a complex with tryptase in mast cells. [Alpha-1-microglobulin]: (Microbial infection) Interacts with hepatitis E virus/HEV protein ORF3. [Inter-alpha-trypsin inhibitor light chain]: (Microbial infection) Interacts with hepatitis E virus/HEV protein ORF3.
Molecular function
Protease inhibitor, Serine protease inhibitor
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