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ASCL1
Loading...Anti-ASCL1 Products
- Mouse Anti-ASCL1 Recombinant Antibody (clone EML200) (MOB-1209CT)
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- Species Reactivity: Human
- Type: Mouse IgG2a
- Application: WB
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- AbPlus™ Anti-Ascl1 Magnetic Beads (VS-0724-YC1216) (VS-0724-YC1216)
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- Target: Ascl1
- Target Species: Mouse, Rat
- Application: IP, Protein Purification
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- Anti-ASCL1 Immunohistochemistry Kit (VS-0525-XY548)
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- Species Reactivity: Human
- Target: ASCL1
- Application: IHC
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- Anti-Mouse ASCL1 Immunohistochemistry Kit (VS-0525-XY549)
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- Species Reactivity: Human, Mouse
- Target: ASCL1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases.
Protein class
Human disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Enteroendocrine cells, Astrocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (SCLC-21H, SH-SY5Y)
Interaction
Efficient DNA binding requires dimerization with another bHLH protein. Forms a heterodimer with TCF3.
Molecular function
Activator, Developmental protein, DNA-binding
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