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CADM1
Anti-CADM1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
CADM1 (Cell Adhesion Molecule 1) is a Protein Coding gene. Diseases associated with CADM1 include Lung Cancer and Retroperitoneal Fibrosis. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and PDZ domain binding. An important paralog of this gene is CADM2.
Protein class
Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Cell type enhanced (Astrocytes, Rod photoreceptor cells, Oligodendrocyte precursor cells, Oligodendrocytes, Bipolar cells, Muller glia cells, Alveolar cells type 1)
Immune cell specificity
Immune cell enhanced (myeloid DC, gdT-cell)
Cell line specificity
Cell line enhanced (CACO-2, WM-115)
Interaction
Homodimer (via Ig-like V-type domain) (PubMed:12050160, PubMed:23871486). Interacts with FARP1 (By similarity). Interacts (via Ig-like V-type domain) with CRTAM (via Ig-like V-type domain); the interaction competes with CRTAM homodimerization and CADM1 homodimerization (PubMed:15811952, PubMed:15781451, PubMed:23871486). Interacts (via C-terminus) with EPB41L3/DAL1 (PubMed:12234973, PubMed:21131357). The interaction with EPB41L3/DAL1 may act to anchor CADM1 to the actin cytoskeleton (PubMed:12234973). Interacts (via C-terminus) with MPP2 (via PDZ domain) (By similarity). Interacts (via C-terminus) with MPP3 (via PDZ domain) (PubMed:13679854). Interacts (via C-terminus) with PALS2 (via PDZ domain) (By similarity). (Microbial infection) Interacts with herpes virus 8 proteins vFLIP and vGPCR; these interactions are essential for NF-kappa-B activation.
Molecular function
Developmental protein
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