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CASP6
Anti-CASP6 Recombinant Antibody Products
- AbPlus™ Anti-CASP6 Magnetic Beads (CBACN-091) (VS-0424-XY42)
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- Target: CASP6
- Target Species: Human, Mouse, Rat
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]
Protein class
Cancer-related genes, Enzymes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Granulosa cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (Karpas-707)
Interaction
Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (p18) and a 11 kDa (p11) subunits (PubMed:19133298, PubMed:19694615, PubMed:20890311). Interacts with BIRC6/bruce (PubMed:15200957). Interacts with RIPK3 (PubMed:32298652). [Caspase-6 subunit p18]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit. [Caspase-6 subunit p11]: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.
Molecular function
Hydrolase, Protease, Thiol protease
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