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CCNA1
Anti-CCNA1 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
CCNA1 (Cyclin A1) is a Protein Coding gene. Diseases associated with CCNA1 include Myeloid Leukemia and Acute Promyelocytic Leukemia. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and Metabolism of proteins. Gene Ontology (GO) annotations related to this gene include protein kinase binding. An important paralog of this gene is CCNA2.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Group enriched (Spermatocytes, Early spermatids, Endometrial ciliated cells, Late spermatids)
Immune cell specificity
Immune cell enriched (basophil)
Cell line specificity
Cell line enhanced (HMC-1, NB-4, THP-1, U-937)
Interaction
Interacts with the CDK2 and the CDC2 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Does not bind CDK4 and CDK5 (in vitro). The cyclin A1-CDK2 complex interacts with transcription factor E2F-1 and RB proteins. Found in a complex with CDK2, CABLES1 and CCNE1 (By similarity). Interacts with INCA1 (PubMed:15159402, PubMed:21540187). Interacts with KLHDC9 (PubMed:15159402).
Molecular function
Cyclin
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