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CD19 & CD3

Anti-CD19 & CD3 Products

anti-CD19 immunotoxin HD37 (scFv)-PE (AGTO-L047E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Anti-Human CD19 Recombinant Antibody (TAB-108CL) (TAB-108CL)
- Derivation: Human
- Species Reactivity: Human
- Type: Antibody
- Application: FC, ADCC, FuncS
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Mouse Anti-CD3 Recombinant Antibody (TAB-0416CL) (TAB-0416CL)
- Application: FC, IB, ELISA
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Mouse Anti-CD3 Recombinant Antibody scFv Fragment (TAB-0416CL-S(P)) (TAB-0416CL-S(P))
- Application: IB, ELISA, FC, FuncS
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Humanized Anti-Human CD3 Recombinant Antibody (TAB-0418CL)
- Type: Humanized Antibody
- Application: ELISA, FC, FuncS
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Mouse Anti-CD19 Recombinant Antibody (TAB-1611CL) (TAB-1611CL)
- Species Reactivity: Human
- Type: Mouse IgG2a, κ
- Application: Depletion, FuncS
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Anti-Human CD19 Recombinant Antibody scFv Fragment (HD37) (TAB-1620CL-S(P))
- Application: FuncS
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Anti-Human CD19 Recombinant Antibody scFv Fragment (cHD37) (TAB-1621CL-S(P))
- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: FuncS
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1612CL-F(E)) (TAB-1612CL-F(E))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Depletion, FuncS
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1613CL-F(E)) (TAB-1613CL-F(E))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: Depletion, FuncS
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1614CL-F(E)) (TAB-1614CL-F(E))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) Fab
- Application: FuncS
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1616CL-F(E)) (TAB-1616CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1617CL-F(E)) (TAB-1617CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1618CL-F(E)) (TAB-1618CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; Fab Fragment (TAB-1619CL-F(E)) (TAB-1619CL-F(E))
- Species Reactivity: Human
- Type: Human Fab
- Application: ELISA, WB
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Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-118CL) (TAB-118CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Fab fragment
- Application: ELISA
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Afuco™ Anti-Human CD19 ADCC Recombinant Antibody (MDX-1342), ADCC Enhanced (AFC-104CL)
- Derivation: Human
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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Mouse Anti-CD19 Recombinant Antibody (clone 32B9) (MOB-1087z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, FC, ICC, IF, FuncS
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Humanized Anti-CD19 Recombinant Antibody (TAB-891) (TAB-891)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1, κ
- Application: ELISA, FC, IP, FuncS, IF, Neut, ICC
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Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1612CL-S(P)) (TAB-1612CL-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized scFv
- Application: Depletion, FuncS
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Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1613CL-S(P)) (TAB-1613CL-S(P))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Depletion, FuncS
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Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1614CL-S(P)) (TAB-1614CL-S(P))
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Mouse scFv
- Application: FuncS
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Human Anti-Human CD3 Recombinant Antibody Fab Fragment (TAB-0532CL-F(E))
- Type: Human antibody
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Anti-Human CD3 Recombinant Antibody (TAB-071LC)
- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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Chimeric Anti-Human CD3 Recombinant Antibody (TAB-072LC)
- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-075LC-S(P)) (TAB-075LC-S(P))
- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-076LC-S(P)) (TAB-076LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-077LC-S(P)) (TAB-077LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-078LC-S(P)) (TAB-078LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-079LC-S(P)) (TAB-079LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-080LC-S(P)) (TAB-080LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Human Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-081LC-S(P)) (TAB-081LC-S(P))
- Derivation: Humanized
- Species Reactivity: Cynomolgus, Human
- Type: Human scFv
- Application: ELISA
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Anti-Human CD19 Recombinant Antibody (TAB-H17) (TAB-H17)
- Derivation: Humanized
- Species Reactivity: Human
- Type: IgG1 - kappa
- Application: IF, IP, Neut, FuncS, ELISA, FC, WB
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Rat Anti-CD3 Recombinant Antibody (clone 17A2) (MOB-0202MC)
- Species Reactivity: Mouse
- Type: Rat IgG2b, κ
- Application: FC, IHC, IP, Activ, CMCD, Depletion
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Chimeric Anti-Human CD3 Recombinant Antibody scFv Fragment (TAB-072LC-S(P))
- Derivation: Chimeric (mouse/human)
- Type: Chimeric antibody (mouse/human)
- Application: ELISA
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Human Anti-Human CD3 Recombinant Antibody (TAB-0532CL)
- Type: Human antibody
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Human Anti-Human CD3 Recombinant Antibody scFv Fragment (TAB-0532CL-S(P))
- Type: Human antibody
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Human Anti-CD3 Recombinant Antibody; Fab Fragment (TAB-084LC-F(E)) (TAB-084LC-F(E))
- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA
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Anti-Human CD3 Recombinant Antibody Fab Fragment (TAB-087LC-F(E)) (TAB-087LC-F(E))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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Human Anti-CD19 Recombinant Antibody (TAB-1612CL) (TAB-1612CL)
- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG1
- Application: Depletion, FuncS
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Human Anti-CD19 Recombinant Antibody (TAB-1613CL) (TAB-1613CL)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG1
- Application: Cyt, FC, FuncS, Inhib
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Human Anti-CD19 Recombinant Antibody (TAB-1614CL) (TAB-1614CL)
- Derivation: Chimeric (mouse/human)
- Species Reactivity: Human
- Type: Chimeric (mouse/human) IgG
- Application: FuncS
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Human Anti-CD19 Recombinant Antibody (TAB-1616CL) (TAB-1616CL)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody (TAB-1617CL) (TAB-1617CL)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody (TAB-1618CL) (TAB-1618CL)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody (TAB-1619CL) (TAB-1619CL)
- Species Reactivity: Human
- Type: Human IgG
- Application: ELISA, WB
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Anti-Human CD3 Recombinant Antibody Fab Fragment (TAB-085LC-F(E)) (TAB-085LC-F(E))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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Anti-Human CD3 Recombinant Antibody Fab Fragment (TAB-086LC-F(E)) (TAB-086LC-F(E))
- Derivation: Humanized
- Type: Humanized antibody
- Application: ELISA, FC
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Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1616CL-S(P)) (TAB-1616CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1617CL-S(P)) (TAB-1617CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1618CL-S(P)) (TAB-1618CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Human Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1619CL-S(P)) (TAB-1619CL-S(P))
- Species Reactivity: Human
- Type: Human scFv
- Application: ELISA, WB
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Anti-CD19 immunotoxin HD37 (IgG)-PAP (AGTO-G076P)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD19 immunotoxin HD37 (IgG)-Sap (AGTO-G076S)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-Human CD19 Recombinant Antibody (HD37) (TAB-1620CL)
- Application: FuncS
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Anti-CD19 immunotoxin HD37 (IgG)-RTA (AGTO-G076R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Anti-CD19 immunotoxin HD37 (IgG)-DT (AGTO-G076D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-073LC-S(P)) (TAB-073LC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-074LC-S(P)) (TAB-074LC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-CD3 Recombinant Antibody (TAB-070LC) (TAB-070LC)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA
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Anti-CD19 immunotoxin HD37 (IgG)-PE (AGTO-G076E)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Function study
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Mouse Anti-CD3 Recombinant Antibody (TAB-073LC) (TAB-073LC)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody (TAB-074LC) (TAB-074LC)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: ELISA, FC
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anti-CD19 immunotoxin HD37 (scFv)-DT (AGTO-L047D)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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anti-CD19 immunotoxin HD37 (scFv)-RTA (AGTO-L047R)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-070LC-S(P)) (TAB-070LC-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (TAB-0422CL-S(P)) (TAB-0422CL-S(P))
- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse scFv
- Application: ELISA
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Mouse Anti-CD3 Recombinant Antibody (TAB-0422CL) (TAB-0422CL)
- Species Reactivity: Human, Cynomolgus monkey
- Type: Mouse IgG
- Application: ELISA
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Anti-Mouse CD3 Recombinant Antibody (Dow2) (TAB-0365CL)
- Application: FC, IHC
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Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1611CL-S(P)) (TAB-1611CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: Depletion, FuncS
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anti-CD19 immunotoxin HD37 (scFv)-Sap (AGTO-L047S)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Mouse Anti-CD19 Recombinant Antibody (clone Taplitumomab) (TAB-174)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: ELISA, IP, FC, FuncS, Neut, IF, ICC
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anti-CD19 immunotoxin HD37 (scFv)-PAP (AGTO-L047P)
- Species Reactivity: Human
- Application: Cytotoxicity assay, Functional assay
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Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1622CL-S(P)) (TAB-1622CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC, Apop, ADCC, FuncS
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Mouse Anti-CD19 Recombinant Antibody; scFv Fragment (TAB-1623CL-S(P)) (TAB-1623CL-S(P))
- Species Reactivity: Human
- Type: Mouse scFv
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0667LY-S(P)) (HPAB-0667LY-S(P))
- Derivation: Mouse
- Species Reactivity: Human, Cynomolgus
- Type: Mouse scfv
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0668LY-S(P)) (HPAB-0668LY-S(P))
- Derivation: Mouse
- Species Reactivity: Human, Cynomolgus
- Type: Mouse scfv
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0669LY-S(P)) (HPAB-0669LY-S(P))
- Derivation: Mouse
- Species Reactivity: Human, Cynomolgus
- Type: Mouse scfv
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0670LY-S(P)) (HPAB-0670LY-S(P))
- Derivation: Mouse
- Species Reactivity: Human, Cynomolgus
- Type: Mouse scfv
- Application: ELISA, FC
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Mouse Anti-CD3 Recombinant Antibody; scFv Fragment (HPAB-0671LY-S(P)) (HPAB-0671LY-S(P))
- Derivation: Mouse
- Species Reactivity: Human, Cynomolgus
- Type: Mouse scfv
- Application: ELISA, FC
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Anti-Mouse CD3 Recombinant Antibody scFv Fragment (Dow2) (TAB-0365CL-S(P))
- Application: IP, IB, FuncS
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TRX4 (Gly-002CL)
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Anti-CD19 (clone B496)-mc-MMAF ADC (ADC-184LZY)
- Target: CD19
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Anti-CD19 (Denintuzumab)-Mc-MMAF ADC (ADC-175LCT)
- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD19 (hBU12)-Mc-MMAF ADC (SGN-19A) (ADC-L034)
- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD19 (hBU12ec)-Mc-vc-PBD ADC (SGN-CD19B) (ADC-L041)
- Target: CD19
- Linker: mc-vc (maleimidocaproyl-valine-alanine)
- Drug: pyrrolobenzodiazepine (PBD) dimers SGD-1882
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Recombinant Anti-CD19× Anti-CD3 Bi-specific T-cell engagers (Tandem Diabody) (BSAB-L011)
- Targets: CD19 & CD3
- Type: Tandem Diabody
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Anti-CD19 (hBU12)-Mc-MMAE ADC (ADC-019LCT)
- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD19 (huB4)-SPDB-DM4 ADC (ADC-020LCT)
- Target: CD19
- Linker: SPDB (N-succinimidyl 4-(2-pyridyldithio)butyrate)
- Drug: DM4 (N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)maytansine)
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Anti-CD19 (clone huB4)-mc-MMAF ADC (ADC-045LZY)
- Target: CD19
- Linker: mc (maleimidocaproyl)
- Drug: MMAF (monomethyl auristatin F)
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Recombinant Anti-CD19 × Anti-CD3 Bispecific Antibody (CrossMab) (CROSS-L024)
- Targets: CD19 & CD3
- Type: CrossMab
- Application: FuncS, Promising therapeutic agent
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Anti-CD19 (hBU12)-mcMMAF ADC (ADC-017LCT)
- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD19 (clone BU12)-MC-MMAF ADC (ADC-189CL)
- Target: CD19
- Linker: Mc (maleimidocaproyl)
- Drug: MMAF (Monomethyl auristatin F)
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Anti-CD19 (clone huB4)-SMCC-DM1 ADC (ADC-157LZY)
- Target: CD19
- Linker: SMCC (4-[N-maleimidomethyl] cyclohexane-1 carboxylhydrazide).
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CD19 (clone hBU12)-vcPAB-MMAE ADC (ADC-150CL)
- Target: CD19
- Linker: VC-PAB (valine-citrulline-p-aminobenzoyloxycarbonyl)
- Drug: MMAE (Monomethyl auristatin E)
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Anti-CD19 (clone MDX1435)-vc-duocarmycin ADC (ADC-163LZY)
- Target: CD19
- Linker: VC (valine-citrulline)
- Drug: duocarmycin
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Anti-CD19 (clone B496)-SPP-DM1 ADC (ADC-181LZY)
- Target: CD19
- Linker: SPP (N-succinimidyl-4-(2-pyridyldithio)pentanoate)
- Drug: DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CD19 (clone B496)-MCC-DM1 ADC (ADC-182LZY)
- Target: CD19
- Linker: MCC (Maleimidomethyl cyclohexane-1-carboxylate)
- Drug: DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
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Anti-CD19 (clone B496)-mc-vc-PABC-MMAE ADC (ADC-183LZY)
- Target: CD19
- Linker: mc-VC-PABC (maleimidocaproyl valine-citrulline-p-aminobenzyl carbamoyl)
- Drug: MMAE (monomethyl auristatin E)
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Anti-CD19 fully human monoclonal antibody MDX-1342 (Gly-011CL)
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For Research Use Only. Not For Clinical Use.

Background

Lymphocytes proliferate and differentiate in response to various concentrations of different antigens. The ability of the B cell to respond in a specific, yet sensitive manner to the various antigens is achieved with the use of low-affinity antigen receptors. This gene encodes a cell surface molecule which assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.

CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains.

Related Diseases

Primary Immunodeficiency