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CD36

Cancer Stem Cell Biomarker Specific Antibody Products AbPlus Recombinant Antibody Products Functional Antibody Products Formats Research Area

Anti-CD36 Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.


CD36 (CD36 Molecule) is a Protein Coding gene. Diseases associated with CD36 include Platelet Glycoprotein Iv Deficiency and Malaria. Among its related pathways are Cytokine Signaling in Immune system and Aryl Hydrocarbon Receptor. Gene Ontology (GO) annotations related to this gene include lipid binding and low-density lipoprotein particle binding. An important paralog of this gene is SCARB2.
Protein class

Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Metabolic proteins, Plasma proteins, Potential drug targets, Transporters

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Adipocytes, Hofbauer cells, Sertoli cells, Cardiomyocytes)

Immune cell specificity

Group enriched (classical monocyte, myeloid DC, intermediate monocyte)

Cell line specificity

Group enriched (ASC diff, HEL)

Interaction

Interacts with THBS1 and THBS2; the interactions mediate the THBS antiangiogenic activity (PubMed:1371676). Upon interaction with a ligand, such as oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42, rapidly forms a complex with TLR4 and TLR6; the complex is internalized and triggers an inflammatory signal. Through its C-terminus, interacts with PTK2, PXN and LYN, but not with SRC. LYN kinase activity is required for facilitating TLR4:TLR6 heterodimerization and signal initiation (PubMed:1371676, 20037584). Upon interaction with ligands such as diacylated lipopeptides, interacts with the TLR2:TLR6 heterodimer (PubMed:16880211). Interacts with CD9, CD81, FCER1G, ITGB2 and/or ITGB2; forming a membrane heteromeric complex required for the internalization of CD36 and its ligands (By similarity). (Microbial infection) Binds to Plasmodium falciparum EMP1.

Molecular function

Receptor

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Related Signaling Pathways
Insulin Signaling Pathway Insulin Signaling Pathway
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