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CD3G
Anti-CD3G Recombinant Antibody Products
- Rabbit Anti-CD3G Recombinant Antibody (clone JB38-29) (MRO-0302-CN)
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- Species Reactivity: Human, Mouse
- Type: Rabbit IgG
- Application: WB, IHC, FC, IP
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- Mouse Anti-CD3G Recombinant Antibody (clone MEM57) (VS-0323-XY4)
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- Species Reactivity: Human
- Type: Mouse IgG2
- Application: ELISA
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For Research Use Only. Not For Clinical Use.
CD3G (CD3g Molecule) is a Protein Coding gene. Diseases associated with CD3G include Immunodeficiency 17 and Enteropathy-Associated T-Cell Lymphoma. Among its related pathways are G-protein signaling N-RAS regulation pathway and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include protein heterodimerization activity and receptor signaling complex scaffold activity. An important paralog of this gene is CD3D.
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (T-cells, dendritic cells)
Immune cell specificity
Group enriched (naive CD8 T-cell, gdT-cell, T-reg, memory CD8 T-cell, naive CD4 T-cell, memory CD4 T-cell, MAIT T-cell)
Cell line specificity
Group enriched (JURKAT, MOLT-4)
Interaction
The TCR-CD3 complex is composed of a CD3D/CD3E and a CD3G/CD3E heterodimers that preferentially associate with TCRalpha and TCRbeta, respectively, to form TCRalpha/CD3E/CD3G and TCRbeta/CD3G/CD3E trimers. In turn, the hexamer interacts with CD3Z homodimer to form the TCR-CD3 complex. Alternatively, TCRalpha and TCRbeta can be replaced by TCRgamma and TCRdelta.
Molecular function
Receptor
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