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CDC42BPB
Anti-CDC42BPB Recombinant Antibody Products
- AbPlus™ Anti-CDC42BPB Magnetic Beads (VS-0724-YC116) (VS-0724-YC116)
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- Target: CDC42BPB
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
CDC42BPB (CDC42 Binding Protein Kinase Beta) is a Protein Coding gene. Diseases associated with CDC42BPB include Myotonic Dystrophy and Lung Large Cell Carcinoma. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is CDC42BPA.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Low cell line specificity
Interaction
Homodimer and homotetramer via the coiled coil regions (PubMed:21949762). Interacts tightly with GTP-bound but not GDP-bound CDC42. Interacts with TJP1, when in the presence of catalytically active CDC42 (By similarity). Forms a tripartite complex with MYO18A and LURAP1 with the latter acting as an adapter connecting CDC42BPB and MYO18A. LURAP1 binding results in activation of CDC42BPB by abolition of its negative autoregulation (PubMed:18854160). Interacts with STRIP1, STRN3 and SIKE1 (PubMed:25743393). Interacts with CPNE4 (via VWFA domain). Interacts with LURAP1. Interacts (via AGC-kinase C-terminal domain) with FAM89B/LRAP25 (via LRR repeat). Forms a tripartite complex with FAM89B/LRAP25 and LIMK1 (By similarity).
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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