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CDC45
Anti-CDC45 Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA replication. Cdc45 is a member of the highly conserved multiprotein complex including Cdc6/Cdc18, the minichromosome maintenance proteins (MCMs) and DNA polymerase, which is important for early steps of DNA replication in eukaryotes. This protein has been shown to interact with MCM7 and DNA polymerase alpha. Studies of the similar gene in Xenopus suggested that this protein play a pivotal role in the loading of DNA polymerase alpha onto chromatin. Alternate splicing results in multiple transcript variants.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Early spermatids, Spermatocytes, Spermatogonia, Erythroid cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (K-562)
Interaction
Associated with ORC2. Interacts with HELB (PubMed:25933514). Component of the CMG helicase complex, composed of the MCM2-7 complex, the GINS complex and CDC45 (By similarity).
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