+ Filter
Loading...
Custom Services order now ship next day

Anti-CHRM1 Recombinant Antibody Products

Anti-CHRM1 Recombinant Antibody Products

Can't find the products you're looking for? Try to filter in the left sidebar.Filter By Tag

More Infomation

Our customer service representatives are available 24 hours a day, from Monday to Sunday. Contact Us

For Research Use Only. Not For Clinical Use.


At Creative Biolabs, we are dedicated to advancing cancer research through the provision of exceptional tools and resources. Our comprehensive collection of anti-CHRM1 antibodies is designed to meet the rigorous demands of modern scientific investigations. With a team of experienced scientists and technicians, we offer unparalleled technical support and a wealth of validated data to facilitate your research endeavors.

CHRM1: A Versatile Therapeutic Target

CHRM1 (Cholinergic Receptor, Muscarinic 1) is a G-protein coupled receptor with a pivotal role in regulating diverse physiological functions. CHRM1's involvement in cardiovascular health, gastrointestinal function, neurological processes, and urinary bladder control has led to its exploration as a potential treatment for conditions such as bradycardia, irritable bowel syndrome, Alzheimer's disease, and overactive bladder. Its broad expression in the body makes it a promising target for therapeutic intervention in a variety of illnesses.

Alternative Names

Muscarinic acetylcholine receptor M1; cholinergic receptor muscarinic 1; cholinergic receptor, muscarinic 1; HM1; M1; M1R.

Background

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 1 is involved in mediation of vagally-induced bronchoconstriction and in the acid secretion of the gastrointestinal tract. The gene encoding this receptor is localized to 11q13.

Protein class

FDA approved drug targets, G-protein coupled receptors

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Excitatory neurons, Inhibitory neurons, Prostatic glandular cells, Breast myoepithelial cells, Melanocytes, Intestinal goblet cells, Oligodendrocyte precursor cells, Astrocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (MCF7, OE19)

Interaction

Interacts with GPRASP2 (PubMed:15086532). Interacts with TMEM147 (PubMed:21056967).

Molecular function

G-protein coupled receptor, Receptor, Transducer

Anti-CHRM1 rAb Products

Creative Biolabs offers a comprehensive suite of high-quality anti-CHRM1 recombinant antibodies designed to facilitate cutting-edge cancer research. Our antibodies are meticulously engineered for optimal specificity and affinity, enabling researchers to investigate the intricate role of CHRM1 in tumorigenesis and progression. With a diverse range of formats and applications, our products are invaluable tools for advancing the understanding of cancer biology and accelerating the development of innovative therapeutic strategies.

Table 1. Featured anti-CHRM1 recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOB-2014z Mouse Anti-CHRM1 Recombinant Antibody (clone 36C10) Human Mouse IgG2a, κ WB, ELISA, IF, IP

Creative Quality Control

Creative Biolabs is a leading provider of high-quality anti-CHRM1 antibodies, meticulously engineered for optimal specificity and affinity. Our whole product line is extensively tested to ensure great performance and dependability across a wide range of applications. By adhering to stringent quality control standards, we empower researchers to achieve consistent and accurate results, driving advancements in their understanding of cancer biology and accelerating the development of innovative therapeutic strategies.

Customer Reviews

Excellent
Ev***n
Mouse Anti-CHRM1 Recombinant Antibody (clone 36C10) (MOB-2014z)>
Creative Biolabs' anti-CHRM1 antibodies have been invaluable for my research. I've used them successfully in both IF and IP assays, and they consistently perform as advertised. The antibodies are highly specific and have a low background signal, making it easy to visualize and analyze my results. I've been particularly impressed with their versatility in different experimental conditions. I would definitely recommend these antibodies to other researchers.
25/May/2023
Excellent
Mo***a
Mouse Anti-CHRM1 Recombinant Antibody (clone 36C10) (MOB-2014z)
Creative Biolabs' anti-CHRM1 antibodies have consistently demonstrated exceptional performance in my immunofluorescence experiments. Their high specificity, sensitivity, and low background noise have enabled me to obtain reliable and reproducible results. I would highly recommend these antibodies to researchers investigating CHRM1.
22/Aug/2023

rAb Production

Creative Biolabs leverages cutting-edge recombinant antibody technology to generate potent and flexible anti-CHRM1 antibodies, customized to fulfill a wide range of research needs. Our innovative technique enables us to provide high-quality anti-CHRM1 antibodies with efficacy and accuracy that help greatly with scientific research and discoveries.

Featured Anti-CHRM1 Recombinant Antibody Production PlatformsFig.1 Milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale anti-CHRM1 recombinant antibody production.

Fig.2 Gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale anti-CHRM1 recombinant antibody production.

rAb Modalities

Creative Biolabs provides a comprehensive selection of excellent anti-CHRM1 recombinant antibodies in numerous forms to help customers with their significant projects.

Fig.3 BCMA antibody production and modalities. (Creative Biolabs Original)Fig.3 CHRM1 antibody production and modalities. (Creative Biolabs Original)

CHRM1-Targeted Drug Information-1

Table 2. Public drug targeting CHRM1.

Highest Phase Mechanism of Action Product Category Condition Organization
Pre-Registered Muscarinic M1 Receptor Agonists
Muscarinic M4 Receptor Agonists
Muscarinic Receptor Antagonists
Signal Transduction Modulators
Fixed-Dose Combinations Psychosis
Schizophrenia
Karuna Pharmaceuticals (Karuna Therapeutics)
Karuna Therapeutics (Originator)
Zai Lab
Zai Lab
Phase II Anticholinergics
Muscarinic M1 Receptor Agonists
Muscarinic Receptor Agonists
Muscarinic Receptor Antagonists
Signal Transduction Modulators
Fixed-Dose Combinations Presbyopia LENZ Therapeutics (Originator)
Presbyopia Therapies (LENZ Therapeutics)
Phase II Acetylcholinesterase (AChE) Inhibitors
Drugs Targeting NMDA Receptors
Drugs Targeting Sodium Channels
Lipid Peroxidation Inhibitors
Muscarinic M1 Receptor Agonists
sigma Non-Opioid Intracellular Receptor 1 (SIGMAR1) Agonists
Signal Transduction Modulators
Fixed-Dose Combinations Dementia, Alzheimer's type Anavex Life Sciences (Originator)
Phase I Muscarinic M1 Receptor Agonists
Muscarinic M4 Receptor Agonists
Muscarinic Receptor Antagonists
Signal Transduction Modulators
Fixed-Dose Combinations Dyskinesia
Psychosis
Schizophrenia
MapLight Therapeutics (Originator)
Preclinical Angiotensin Converting Enzyme (ACE; DCP) Inhibitors
Muscarinic M1 Receptor Agonists
Signal Transduction Modulators
Natural Products
Oligopeptides, less than 10 AA
Type-C Natriuretic Peptides
Hypertension Instituto Butantan
Universidade de Sao Paulo (USP)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

CHRM1-Targeted Drug Information-2

Table 3. Clinical drug targeting CHRM1.

Highest Phase Mechanism of Action Product Category Condition Organization
Biological Testing Muscarinic M1 Receptor Antagonists
Signal Transduction Modulators
Polypeptides, from 10 AA to 40 AA Cataract
Chronic obstructive pulmonary disease (COPD)
Dementia, Alzheimer type
Ulcer, peptic
Shanghai Jiao Tong University (SJTU) (Originator)
Biological Testing Muscarinic M1 Receptor Ligands
Muscarinic M2 Receptor Ligands
Muscarinic M3 Receptor Antagonists
Muscarinic M4 Receptor Ligands
Muscarinic M5 Receptor Ligands
Signal Transduction Modulators
Chronic obstructive pulmonary disease (COPD) Pfizer (Originator)
Biological Testing Muscarinic M1 Receptor Agonists
Signal Transduction Modulators
Merck & Co (Originator)
Biological Testing Muscarinic M1 Receptor Agonists
Signal Transduction Modulators
Cognitive disorders AstraZeneca (Originator)

(Disclaimer: The information in this table is just for knowledge sharing and not for marketing or sales purposes.)

Creative Biolabs is a prominent supplier of cutting-edge antibody solutions, fusing a strong theoretical foundation with a wealth of real-world experience. Our economical, high-quality anti-CHRM1 antibodies are designed to meet the exacting requirements of the most recent studies. Don't hesitate to get in touch with us to discover more about our extensive product line and how our antibodies could assist you in furthering your research.

  • 0
  • 0
Cart
    Go to compare

    Go to compare