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CLEC5A
Anti-CLEC5A Recombinant Antibody Products
- AbPlus™ Anti-CLEC5A Magnetic Beads (VS-0424-XY67) (VS-0424-XY67)
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- Target: CLEC5A
- Target Species: Human
- Application: IP, Protein Purification
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For Research Use Only. Not For Clinical Use.
The antibodies specific for myeloid DAP-12 associating lectin (MDL-1) are using in treatment of immune disorders, in particular, infectious diseases and sepsis.
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Langerhans cells, Macrophages, Hofbauer cells)
Immune cell specificity
Immune cell enriched (classical monocyte)
Cell line specificity
Group enriched (HL-60, U-937)
Interaction
Monomer (PubMed:21566123). Homodimer (PubMed:21566123). The majority of CLEC5A is expressed as a monomeric form on macrophages (PubMed:21566123). Interacts with TYROBP/DAP12 (PubMed:10449773). The interaction with TYROBP is required for CLEC5A cell surface expression (PubMed:10449773). Interacts with HCST/DAP10 (By similarity). Forms a CLEC5A/TYROBP/HCST trimolecular complex depending almost solely on TYROBP (By similarity). (Microbial infection) Interacts with dengue virus envelope protein E (PubMed:18496526, PubMed:21566123).
Molecular function
Host cell receptor for virus entry, Receptor
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