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CRTC3
Anti-CRTC3 Recombinant Antibody Products
- Rabbit Anti-NHP CRTC3 Recombinant Antibody (VS-1024-XY139) (VS-1024-XY139)
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- Species Reactivity: Human, Mouse, Non-human primate, Rat
- Type: Rabbit IgG
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.
This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Protein class
Cancer-related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes)
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Cell line enhanced (HeLa)
Interaction
Binding, as a tetramer, through its N-terminal region, with the bZIP domain of CREB1 enhances recruitment of TAF4 to the promoter (PubMed:14506290). 'Arg-314' in the bZIP domain of CREB1 is essential for this interaction (PubMed:14506290). Interacts (when phosphorylated at Ser-162 and Se-273) with 14-3-3 proteins (PubMed:30611118). Interacts with YWHAE (PubMed:30611118). Interacts (when phosphorylated at Ser-391) with phosphatase PP2A catalytic subunit PPP2CA and regulatory subunits PPP2R1A and PPP2R2A (PubMed:30611118). Interacts, via the N-terminal with the ankyrin repeats of BCL3, to form a complex with CREB1 on CRE and TxRE responsive elements and represses HTLV-1 LTR-mediated transcription (PubMed:17644518). (Microbial infection) Interacts with HTLV-1 protein Tax; this interaction enhances tax transcriptional activity.
Molecular function
Activator
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