CTLA4

Creative Biolabs provides a broad selection of high-quality recombinant antibodies targeting CTLA4, tailored to meet the needs of biomedical researchers and institutions. These antibodies are crafted for maximum specificity and reliability across various applications. Our commitment to advancing scientific research is reflected in the innovative solutions we offer, enabling researchers to drive progress in immunology and cancer studies. By utilizing our CTLA4 antibodies, you can elevate your research and contribute to deeper insights into immune regulation.

CTLA4: A Key Immune Checkpoint of Immune-Related Disease

CTLA4 (cytotoxic T-lymphocyte-associated protein 4) is a crucial immune checkpoint protein involved in regulating immune responses. It is a transmembrane protein consisting of an extracellular domain, a transmembrane domain, and an intracellular domain. The extracellular domain binds to ligands, while the intracellular domain interacts with signaling molecules to modulate T cell activation. Research on CTLA4 is pivotal for understanding immune regulation and tolerance. Blocking CTLA4 has proven effective in cancer immunotherapy by preventing its inhibitory effect and boosting the anti-tumor immune response. Additionally, a deeper understanding of CTLA4's structure and function can aid in developing innovative therapies for a range of immune-related diseases.

Alternative Names

Cytotoxic T-lymphocyte associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Background

This gene is a member of the immunoglobulin superfamily and encodes a protein that transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Anti-CTLA4 rAb Products

Our company offers high-quality anti-CTLA4 recombinant antibodies, supporting research and the development of therapies targeting this important molecule.

Creative Quality Control

To meet our customers' expectations for antibody quality, we have implemented a rigorous quality management system. This approach guarantees the excellence of our products, allowing researchers to conduct their work with greater efficiency and ease.

Customer Reviews

Excellent

L**en
Anti-Human CTLA4 Recombinant Antibody (Ipilimumab) (Cat#: TAB-067)

For my research, I utilized the anti-human CTLA4 recombinant antibody to investigate CTLA4 expression in tumor tissues. The antibody yielded outstanding results in both WB and IF assays, delivering precise and distinct signals, which greatly contributed to the accuracy of my study.

18/Dec/2021

Excellent

D**e
Anti-Human CTLA4 Recombinant Antibody (Ticilimumab (Tremelimumab)) (Cat#: TAB-206)

The anti-human CTLA4 recombinant antibody played a crucial role in my research. I utilized it across various experiments, including immunofluorescence, immunoprecipitation, and ELISA. It provided precise and consistent results when detecting specific cells or tissues, making it an indispensable tool that significantly advanced my studies.

9/Oct/2021

Excellent

C**al
Mouse Anti-CTLA4 Recombinant Antibody (Cat#: TAB-195CL)

As a researcher, I incorporated the mouse anti-CTLA4 recombinant antibody into my experiments, specifically employing it in an ELISA assay to detect CTLA4 expression in immune cells. The results were exceptional. This antibody showed impressive specificity and sensitivity, providing accurate and reliable data for my research. It has proven to be an invaluable tool in my work.

15/Jul/2022

rAb Production

With years of expertise in process optimization, including the development of expression vectors, screening of transfected cell lines, and antibody purification, we are committed to offering comprehensive services to biomedical researchers. From gene synthesis to the final production of high-quality antibodies, we strive to support your research with excellence at every step.

Featured Anti-CTLA4 Recombinant Antibody Production Platforms
Fig.5 Milligram-scale recombinant antibody production.

Fig.6 Gram-scale recombinant antibody production

rAb Modalities

We are fully dedicated to delivering premium recombinant antibodies in multiple formats to researchers. Our goal is to address the varied needs of our clients and equip them with the crucial tools required to advance their research projects.

Fig.7 Full Length Anti-CTLA4 Recombinant Antibody Production and Modalities

Drug Information Targeting CTLA4

Table 1. Therapeutic approaches targeting CTLA4 in clinical development.

If you would like more information about our anti-CTLA4 recombinant antibody products, please don't hesitate to reach out to us at any time. Our team is here to provide assistance and address any inquiries you may have, and we eagerly anticipate the opportunity to establish a mutually beneficial partnership with you.