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CX3CL1
Anti-CX3CL1 Recombinant Antibody Products
- Human Anti-CX3CL1 Recombinant Antibody (HPAB-1500-FY) (HPAB-1500-FY)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized IgG
- Application: Neut
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- Human Anti-CX3CL1 Recombinant Antibody; Fab Fragment (HPAB-1500-FY-F(E)) (HPAB-1500-FY-F(E))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Humanized Fab
- Application: Neut
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- Human Anti-CX3CL1 Recombinant Antibody; scFv Fragment (HPAB-1500-FY-S(P)) (HPAB-1500-FY-S(P))
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Human scFv
- Application: Neut
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For Research Use Only. Not For Clinical Use.
Fractalkine is a unique Th1 CX3C chemokine known to induce adhesion and migration of leukocytes mediated by both, a membrane-bound and soluble form, respectively.
Protein class
Plasma proteins
Predicted location
Membrane, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Adipocytes, Breast glandular cells, Club cells, Basal respiratory cells, Breast myoepithelial cells, Basal prostatic cells, Endothelial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Group enriched (EFO-21, HDLM-2, Hep G2, RPTEC TERT1, SK-BR-3)
Interaction
Monomer (PubMed:9931005). Forms a ternary complex with CX3CR1 and ITGAV:ITGB3 or ITGA4:ITGB1 (PubMed:23125415). (Microbial infection) Interacts with pox virus crmD; this inhibits cell migration mediated by CX3CL1. (Microbial infection) Interacts (via N-terminus) with human cytomegalovirus (HHV-5) US28.
Molecular function
Cytokine
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Related Signaling Pathways
TNF Signaling Pathway