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DOK2
Anti-DOK2 Recombinant Antibody Products
- Mouse Anti-NHP DOK2 Recombinant Antibody (clone OTI2D10) (VS-1024-XY171)
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- Species Reactivity: Dog, Human, Mouse, Non-human primate, Rat
- Type: Mouse IgG1
- Application: WB
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210(bcr/abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (NK-cells, Langerhans cells, Macrophages, Kupffer cells, T-cells, Hofbauer cells, dendritic cells)
Immune cell specificity
Immune cell enhanced (eosinophil)
Cell line specificity
Cell line enhanced (HDLM-2, HEL, HMC-1, JURKAT, THP-1, U-937)
Interaction
Interacts with phosphorylated RASGAP and EGFR. Interacts with RET and NCK. Interacts (via PH domain) with TEK/TIE2 (tyrosine phosphorylated) (By similarity). (Microbial infection) Interacts with Herpes simplex virus 1 (HHV-1) protein UL46; this interaction induces DOK2 phosphorylation and subsequent degradation.
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