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DSP
Anti-DSP Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Squamous epithelial cells, Basal keratinocytes, Cardiomyocytes)
Immune cell specificity
Immune cell enriched (naive B-cell)
Cell line specificity
Cell line enhanced (BEWO, HaCaT, HBEC3-KT, hTCEpi, SuSa)
Interaction
Homodimer. Interacts with COL17A1 (via cytoplasmic region). Associates (via C-terminal) with KRT5-KRT14 (via rod region), KRT8-KRT18 and VIM intermediate filaments. Interacts with DSC2. Interacts with PKP2. Interacts weakly with TMEM65 (By similarity).
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