Anti-Human EGFR Recombinant Antibody (Modotuximab) (CAT#: TAB-H49)

Recombinant Chimeric antibody to Human EGFR

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Custom Production

We specialize in custom recombinant antibody production, offering seamless execution from provided sequences to high-quality antibody deliverables, ensuring optimal yield and purity.

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We require custom production
  • Published Data
  • Tested Data
  • Gene Expression
  • Datasheet
  • MSDS
  • COA

Figure 1 Sym004 Internalizes and Degrades EGFRvIII.

Figure 1 Sym004 Internalizes and Degrades EGFRvIII.

The cell line NR6M was treated with negative control mAb (Neg Ctrl mAb), futuximab, modotuximab, or Sym004 for 24 or 48 h, followed by harvest of cell lysates and detection of EGFRvIII by Western blot. Data are represented as means ± SEM. Statistically significant differences from untreated controls are indicated by asterisks *p < 0.05, **p < 0.01, ***p < 0.001.

Keir, S. T., Chandramohan, V., Hemphill, C. D., Grandal, M. M., Melander, M. C., Pedersen, M. W., ... & Bigner, D. D. (2018). Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models. Journal of neuro-oncology, 138(3), 489-498.


Specifications

  • Host Species
  • undefined
  • Derivation
  • Chimeric
  • Type
  • IgG1 - kappa
  • Specificity
  • EGFR (epidermal growth factor receptor, receptor tyrosine-protein kinase erbB-1, ERBB1, HER1, HER-1, ERBB) [Homo sapiens]
  • Species Reactivity
  • Human
  • Applications
  • FuncS, IF, Neut, ELISA, FC, IP, IHC
  • Generic Name
  • modotuximab
  • Related Disease
  • Colorectal cancers

Product Property

  • Purity
  • >95.0%, determined by analysis by RP-HPLC & analysis by SDS-PAGE.

Applications

  • Application Notes
  • The EGFR antibody has been reported in applications of WB.

Target

  • Alternative Names
  • modotuximab;EGFR;epidermal growth factor receptor;epidermal growth factor receptor (avian erythroblastic leukemia viral (v erb b) oncogene homolog) , ERBB;ERBB1;erythroblastic leukemia viral (v erb b) oncogene homolog (avian);proto-oncogene c-ErbB-1;cell

Related Resources

  • Biosimilar Overview
  • Related Diseases
  • Related Signaling Pathways
Please refer to Modotuximab Overview to learn more about the mechanism of action, clinical projects, and approved drugs of Modotuximab.

Product Notes

This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:

• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production

See more details about Hi-Affi™ recombinant antibody benefits.

Downloads

Download resources about recombinant antibody development and antibody engineering to boost your research.

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Afuco™ Anti-EGFR ADCC Recombinant Antibody, ADCC Enhanced (AFC-TAB-H49)
This product is an ADCC enhanced antibody produced by our Afuco™ platform. Recombinant Chimeric antibody to Human EGFR.

See other products for "EGFR"

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TAB-302MZ-F(E) Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-302MZ-F(E)) ELISA Chimeric (mouse/human) Fab
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To accurately reference this product in your publication, please use the following citation information:

(Creative Biolabs Cat# TAB-H49, RRID: AB_3112036)

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