Anti-Human EGFR Recombinant Antibody (Modotuximab)

Published Data
Tested Data
Gene Expression
Datasheet
MSDS
COA

Figure 1 Sym004 Internalizes and Degrades EGFRvIII.

The cell line NR6M was treated with negative control mAb (Neg Ctrl mAb), futuximab, modotuximab, or Sym004 for 24 or 48 h, followed by harvest of cell lysates and detection of EGFRvIII by Western blot. Data are represented as means ± SEM. Statistically significant differences from untreated controls are indicated by asterisks *p < 0.05, **p < 0.01, ***p < 0.001.

Keir, S. T., Chandramohan, V., Hemphill, C. D., Grandal, M. M., Melander, M. C., Pedersen, M. W., ... & Bigner, D. D. (2018). Sym004-induced EGFR elimination is associated with profound anti-tumor activity in EGFRvIII patient-derived glioblastoma models. Journal of neuro-oncology, 138(3), 489-498.

SDS-PAGE

Figure 1 Anti-Human EGFR Recombinant Antibody (TAB-H49) in SDS-PAGE

Lane 1: Non-reduced
Lane 2: Reduced

SEC-HPLC

Figure 2 Anti-Human EGFR Recombinant Antibody (TAB-H49) in HPLC

The purity of TAB-H49 was greater than 95% as determined by SEC-HPLC.

Subcellular Location and Protein Expression

Figure 1 IF staining of human cell line A-431
(Immunofluorescent staining of human cell line A-431 shows localization to plasma membrane & cell junctions.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/144_E9_2_selected.jpg

Figure 2 IF staining of human cell line U-251 MG
(Immunofluorescent staining of human cell line U-251 MG shows localization to plasma membrane.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/143_E9_1_blue_red_green.jpg

Normal Tissue

Figure 3 Colon
(Glandular cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_9_3.jpg

Figure 4 Liver
(Cholangiocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_7_4.jpg

Figure 5 Kidney
(Bowman's capsule
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Collecting ducts
Staining:Medium
Intensity: Strong
Quantity: <25%
Distal tubules
Staining:Medium
Intensity: Strong
Quantity: <25%
Proximal tubules (cell body)
Staining:Medium
Intensity: Strong
Quantity: <25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_9_5.jpg

Figure 6 Testis
(Leydig cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Pachytene spermatocytes
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%
Round or early spermatids
Staining:Medium
Intensity: Moderate
Quantity: 75%-25%)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_6_6.jpg

Figure 7 Placenta
(Cytotrophoblasts
Staining:High
Intensity: Strong
Quantity:>75%
Decidual cells
Staining:Medium
Intensity: Moderate
Quantity:>75%
Hofbauer cells
Staining:High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - cell body
Staining:High
Intensity: Strong
Quantity:>75%
Syncytiotrophoblasts - microvilli
Staining:High
Intensity: Strong)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_1_7.jpg

Figure 8 Lymph node
(Non-germinal center cells
Staining:Medium
Intensity: Strong
Quantity: <25%
Location: Cytoplasmic/membranous)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/images/18530/41191_A_7_8.jpg

RNA Expression

Figure 9 RNA cell line category: Cell line enriched (A-431)
(Cell lines ordered by descending RNA expression order.)
* Image credit: Human Protein Atlas https://v21.proteinatlas.org/ENSG00000146648-EGFR

Datasheet

MSDS

Certificate of Analysis Lookup
To download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number

CAT	Product Name	Application	Type
NABG-056	Recombinant Anti-Mouse Egfr VHH Single Domain Antibody	ELISA, IHC, FC, FuncS	Llama VHH
PNBL-016	Recombinant Anti-Human EGFR VHH Single Domain Antibody (7D12)	WB, ELISA	Llama VHH
PNBL-017	Recombinant Anti-Human EGFR VHH Single Domain Antibody (9G8)	FuncS, ELISA, IF	Llama VHH
PNBL-018	Recombinant Anti-Human EGFR VHH Single Domain Antibody (EgA1)	FuncS, SPR	Llama VHH
TAB-015MZ-VHH	Anti-Human EGFR Recombinant Antibody (PMP7A5)	sELISA	Single domain antibody

CAT	Product Name	Application	Type
PABZ-039	Mouse Anti-EGFR Recombinant Antibody (clone mAb528)	FC	Mouse IgG
PABW-039	Human Anti-EGFR Recombinant Antibody (clone Cetuximab (IMC-C225))	FuncS	Chimeric (mouse/human) IgG
PABC-040	Human Anti-EGFR Recombinant Antibody (clone MR1)	Block	Human IgG
PFBW-088	Mouse Anti-EGFR Recombinant Antibody (clone 7A7); Fab Fragment	ELISA, WB	Mouse Fab
MOB-0094MZ	Recombinant Mouse Anti-EGFR Antibody (clone FGF-R2)	ELISA, IHC-P, FC	Mouse antibody

CAT	Product Name	Application	Type
PFBW-171	Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (PFBW-171)	WB	Mouse Fab
HPAB-N0080-YC-S(P)	Human Anti-EGFR Recombinant Antibody (clone NOV004YC); scFv Fragment	ELISA, DB, FC, Inhib	Human scFv
HPAB-0704-FY-F(E)	Mouse Anti-EGFR Recombinant Antibody (clone AB003); scFv Fragment	ELISA	Mouse scFv
PSBS-0060	Human Anti-EGFR Recombinant Antibody (Clone FM318); scFv Fragment	ELISA, IB, FuncS	Human scFv
PSBS-0061	Human Anti-EGFR Recombinant Antibody (Clone FM329); scFv Fragment	ELISA, FuncS	Human scFv

CAT	Product Name	Application	Type
TAB-270MZ	Human Anti-EGFR Recombinant Antibody (TAB-270MZ)	ELISA	Human antibody
TAB-299MZ-F(E)	Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-299MZ-F(E))	Internalization Assay	Human Fab
TAB-313MZ-F(E)	Anti-Human EGFR Recombinant Antibody Fab Fragment (EG-19-11)	ELISA, FC	Human antibody
TAB-314MZ-F(E)	Anti-Human EGFR Recombinant Antibody Fab Fragment (EG-26-11)	ELISA, FC	Human antibody
PABX-053	Recombinant Human Anti-EGFR Antibody (DL11)	WB, ELISA, FuncS	IgG

CAT	Product Name	Application	Type
TAB-272MZ	Human Anti-EGFR Recombinant Antibody (TAB-272MZ)	FuncS	Chimeric (mouse/human) IgG
TAB-302MZ	Human Anti-EGFR Recombinant Antibody (TAB-302MZ)	ELISA	Chimeric (mouse/human) IgG1
TAB-272MZ-S(P)	Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-272MZ-S(P))	FuncS	Mouse scFv
TAB-302MZ-S(P)	Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-302MZ-S(P))	ELISA	Mouse scFv
TAB-302MZ-F(E)	Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-302MZ-F(E))	ELISA	Chimeric (mouse/human) Fab

CAT	Product Name	Application	Type
TAB-274MZ	Human Anti-EGFR Recombinant Antibody (TAB-274MZ)	FC	Humanized IgG
TAB-297MZ	Anti-Human EGFR Recombinant Antibody (H225)	ELISA, WB	Humanized antibody
TAB-274MZ-S(P)	Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P))	FC	Humanized scFv
TAB-274MZ-F(E)	Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-274MZ-F(E))	FC	Humanized Fab
TAB-300MZ-F(E)	Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-300MZ-F(E))	ELISA	Humanized Fab

CAT	Product Name	Application	Type
TAB-310MZ-F(E)	Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-310MZ-F(E))	ELISA	Mouse Fab
TAB-311MZ-F(E)	Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-311MZ-F(E))	ELISA	Mouse Fab
TAB-312MZ-F(E)	Mouse Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-312MZ-F(E))	ELISA	Mouse Fab
TAB-316MZ-F(E)	Anti-Human EGFR Recombinant Antibody Fab Fragment (07D06)	WB, MTT assay
TAB-317MZ-F(E)	Anti-Human EGFR Recombinant Antibody Fab Fragment (12D03)	WB, MTT assay

CAT	Product Name	Application	Type
Gly-055LC	Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Chimeric antibody (mouse/human)
Gly-144LC	Recombinant Anti-Human EGFR Antibody (Fc glycosylation)	ELISA	Humanized antibody

CAT	Product Name	Application	Type
Gly-055LC-1	Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated)	ELISA	Chimeric antibody (mouse/human)

CAT	Product Name	Application	Type
Gly-167LC	Recombinant Anti-Human EGFR Antibody (Non-glycosylated)	ELISA	Human antibody

CAT	Product Name	Application	Type
BRD-0183MZ	Chicken Anti-EGFR Polyclonal IgY	WB	Chicken antibody
BRD-0668MZ	Chicken Anti-EGFR Polyclonal IgY	WB	Chicken antibody

CAT	Product Name	Application
MHC-LC773	A*0201/Human EGFR (YLNTVQPTCV) MHC Tetramer	FCM
MHC-LC4545	PE-DQB1*03:02/Human EGFR (SRALEEKKGNYVVTHG) MHC Tetramer	FCM
MHC-YF409	A*02:01/Human EGF-R-479 (KLFGTSGQKT) MHC Pentamer	FCM

CAT	Product Name	Application	Type
NEUT-722CQ	Rabbit Anti-EGFR Recombinant Antibody (clone CBL1011)	Neut	Rabbit IgG
NEUT-723CQ	Mouse Anti-EGFR Recombinant Antibody (clone CBL931)	WB, IP, IHC, ICC, Neut	Mouse IgG1
NEUT-724CQ	Rabbit Anti-EGFR Recombinant Antibody (clone D1D4J)	IF, FC, WB, IP, Neut	Rabbit IgG

CAT	Product Name	Application	Type
MOR-1101	Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone DS1101AB)	IHC-P	Rabbit IgG
MOR-4520	Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH28DS)	IF, ICC, FC	Rabbit IgG
MOR-4675	Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH189DS)	WB, IF, ICC, FC	Rabbit IgG
MOR-4676	Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH190DS)	WB, IF, ICC, FC	Rabbit IgG
MOR-0033-FY	Rabbit Anti-EGFR Recombinant Antibody (clone AFY0004)	ICC, IHC, WB	Rabbit IgG

CAT	Product Name	Application	Type
HPAB-0010-YC-F(E)	Mouse Anti-EGFR Recombinant Antibody (clone L211C); Fab Fragment	ELISA, FC	Mouse Fab
HPAB-0011-YC-F(E)	Human Anti-EGFR Recombinant Antibody (clone Pep 1); Fab Fragment	FC	Human Fab
HPAB-0012-YC-F(E)	Human Anti-EGFR Recombinant Antibody (clone Pep 2); Fab Fragment	FC	Human Fab
HPAB-0013-YC-F(E)	Human Anti-EGFR Recombinant Antibody (clone Pep 3); Fab Fragment	FC	Human Fab
HPAB-0014-YC-F(E)	Human Anti-EGFR Recombinant Antibody (clone Pep 4); Fab Fragment	FC	Human Fab

CAT	Product Name	Application	Type
AFC-TAB-165	Afuco™ Anti-EGFR ADCC Recombinant Antibody (Matuzumab), ADCC Enhanced	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody
AFC-TAB-464CQ	Afuco™ Anti-EGFR ADCC Recombinant Antibody (Tomuzotuximab), ADCC Enhanced	ELISA, IHC, FC, IP, IF, FuncS	ADCC enhanced antibody
AFC-TAB-710	Afuco™ Anti-EGFR ADCC Recombinant Antibody (Nimotuzumab), ADCC Enhanced	ELISA, IP, FC, FuncS, Neut, IF	ADCC enhanced antibody
AFC-TAB-753	Afuco™ Anti-EGFR ADCC Recombinant Antibody (Imgatuzumab), ADCC Enhanced	Neut, ELISA, IF, IP, FuncS, FC	ADCC enhanced antibody
AFC-TAB-H35	Afuco™ Anti-EGFR ADCC Recombinant Antibody (Futuximab), ADCC Enhanced	FuncS, IF, Neut, ELISA, FC, IP	ADCC enhanced antibody

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

Anti-Human EGFR Recombinant Antibody (Modotuximab) (CAT#: TAB-H49)

Subcellular Location and Protein Expression

Normal Tissue

RNA Expression

Specifications

Product Property

Applications

Target

Related Resources

Product Notes

Downloads

See other products for "Modotuximab"

See other products for "EGFR"

Single-domain Antibody

Recombinant Antibody

scFv Fragment Antibody

Human Antibody

Chimeric Antibody

Humanized Antibody

Mouse Antibody

Fc Glycosylation

High-mannose Glycoform

Deglycosylated Antibody (Non-glycosylated IgGs)

Chicken IgY Antibody

MHC Tetramer for Cancer

Neutralizing Antibody

Rabbit Monoclonal Antibody

Fab Fragment Antibody

ADCC Enhanced Antibody

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