Anti-Human EGFR Recombinant Antibody (LA22) (CAT#: TAB-277MZ)
This monoclonal antibody LA22 that can specifically bind to EGFR can be conjugated with a cytotoxic agent for treating cancers.
Specific Inquiry
Cyt
Figure 1 demonstrates the cytotoxic effects of anti-EGFR monoclonal antibodies conjugated with pingyangmycin or mitomycin C on human epidermoid carcinoma cells.
FuncS
Figure 2 illustrates the dose-dependent cytotoxic effect of monoclonal antibody LA22 conjugated with pingyangmycin or mitomycin C on human epidermoid carcinoma cells.
Cyt
Figure 3 shows the in vitro cytotoxic effect of LA22-MMC immunoconjugate, MMC and naked mAb LA22 on A431 cells.
FuncS
Figure 4 illustrates the in vivo tumor toxicity effect of LA22-MMC on female Balb/c mice.
FuncS
Figure 5 shows the in vitro cytotoxic effect of LA22-MMC immunoconjugate on human epidermoid carcinoma cells.
Specifications
- Host Species
- Mouse
- Specificity
- Human
- Clone
- LA22
- Applications
- Cyt, FuncS
- Related Disease
- Cancers such as glioblastoma or cancer of the lung, breast, head and neck, and bladder
Applications
- Application Notes
- This antibody has been reported for use in Cytotoxicity, Functional Assay.
Target
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1; avian erythroblastic leukemia viral (v-erb-b) oncogene homolog
- Gene ID
- 1956
- UniProt ID
- P00533
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Cushing Syndrome
JAK-STAT Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
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Flow Cytometry (FC) related Products
| CAT | Product Name | Application | Type |
|---|---|---|---|
| TAB-003 | Anti-Human EGFR Recombinant Antibody (Cetuximab) | IF, IP, Neut, FuncS, ELISA, FC, ICC | IgG1 - kappa |
| TAB-H49 | Anti-Human EGFR Recombinant Antibody (Modotuximab) | FuncS, IF, Neut, ELISA, FC, IP, IHC | IgG1 - kappa |
| TAB-272MZ | Human Anti-EGFR Recombinant Antibody (TAB-272MZ) | FuncS | Chimeric (mouse/human) IgG |
| TAB-302MZ | Human Anti-EGFR Recombinant Antibody (TAB-302MZ) | ELISA | Chimeric (mouse/human) IgG1 |
| TAB-308MZ | Human Anti-EGFR Recombinant Antibody (TAB-308MZ) | FuncS | Chimeric antibody (mouse/human) |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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