Products

J2898A-SMCC-DM1 (ADC-047LZY)

This ADC product is composed of an anti-EGFR antibody (clone J2898A) conjugated via SMCC linker to DM1 (J2898A-SMCC-DM1). It is in Phase I clinical trials and has demonstrated a response in Solid tumors treatment by a MOA (Mechanism of Action) of microtubules depolymerizing.      

  • Datasheet

Specifications
Antibody Overview
Humanized Anti-EGFR Antibody, J2898A
Clone
J2898A
Linker
SMCC (N-succinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate)
Linker Class/Description
Class: Noncleavable linker
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation
Drug
DM1(N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)-maytansine)
Drug Class/Description
Class: Maytansinoid
Description: Maytansinoids are a group of cytotoxins structurally similar to rifamycin, geldanamycin, and ansatrienin. The eponymous natural cytotoxic agent maytansine is a 19-member lactam (ansa
macrolide) structure originally isolated from the Ethiopian shrub Maytenus ovatus. Maytansinoids can bind to tubulin at or near the vinblastine-binding site, which interfere the formation of microtubules and depolymerize already formed microtubules, inducing mitotic arrest in the intoxicated cells
Target
Introduction
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Alternative Names
EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
Entrez Gene ID
1956
UniProt ID
P00533

For lab research use only, not for diagnostic, therapeutic or any in vivo human use.

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