This ADC product is composed of an anti-EGFR antibody conjugated via mc linker to MMAF(Abl-mcMMAF). It has demonstrated a response in treatment by a MOA (Mechanism of Action) as microtubule inhibitor.
Specifications
- Antibody Overview
- Humanized Anti-EGFR Antibody
- Linker
- Mc (maleimidocaproyl)
- Linker Class/Description
- Class: Noncleavable linkers
Description: Noncleavable linker is considered noncleavable-meaning linker cleavage, and payload release does not depend on the differential properties between the plasma and some cytoplasmic compartments. Instead, the release of the cytotoxic drug is postulated to occur after internalization of the ADC via antigen-mediated endocytosis and delivery to lysosomal compartment, where the antibody is degraded to the level of amino acids through intracellular proteolytic degradation.
- Drug
- MMAF (Monomethyl auristatin F)
- Drug Class/Description
- Class: Auristatin
Description: Auristatins are water-soluble dolastatin analogs of dolastatin 10. Dolastatin 10 belongs to dolastatin family and it can powerfully bind to tubulin, thus inhibiting polymerization mediated through the binding to the vinca alkaloid binding domain, and causes cell to accumulate in metaphase arrest.
Target
- Introduction
- The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2
- Entrez Gene ID
- 1956
- UniProt ID
- P00533
For lab research use only, not for diagnostic, therapeutic or any in vivo human use.
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