Anti-Human EGFR Recombinant Antibody (ABT-806) (CAT#: TAB-228CL)
Recombinant Chimeric (human/mouse) monoclonal antibody expressed in CHO binding to Human EGFR. This is a novel EGFR antibody that selectively targets a tumor-selective epitope suggesting that a mAb 806-based therapeutic would retain antitumor activity without the on-target toxicities associated with EGFR inhibition.
Specific Inquiry
WB
Figure 1 ABT-806 is more potent than cetuximab at inhibiting EGFRvIII tumor growth and pEGFR expression.
Total and pEGFR status in SN0199 tumors were assessed following treatment of mice with ABT-806 at 40 mg/kg. Antibodies were administered Q3D×2, with tumors harvested 72 hour after the final dose.
Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.
IHC
Figure 2 ABT-806 downregulates tumor wild-type EGFR and pEGFR in SCC15 tumors grown as implants in mice.
IHC images of representative samples derived from harvested tumors 120 hours after treatment. IHC results were obtained by semiquantitative assessment of the
percent positive cells within viable areas across treatment groups at various time points.
Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.
Specifications
- Host Species
- Human
- Derivation
- Humanized
- Type
- Antibody
- Species Reactivity
- Human
- Applications
- WB, IHC
- Related Disease
- Cancer
Product Property
- Purity
- >95%, by SDS-PAGE, under reducing conditions
- Storage
- 4°C. For long term storage, aliquot and store at -20°C. Repeated thawing and freezing must be avoided.
Applications
- Application Notes
- This antibody has been reported for use in Western Blot and Immunohistochemistry.
Target
- Alternative Names
- EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;
- Gene ID
- 1956
- UniProt ID
- P00533
Related Resources
Bladder Cancer
Non-small Cell Lung Cancer
Pancreatic Cancer
Hepatocellular Carcinoma
Cushing Syndrome
JAK-STAT Signaling Pathway
Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Downloads
Download resources about recombinant antibody development and antibody engineering to boost your research.
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Chimeric Antibody
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Antibody Magnetic Beads
| CAT | Product Name | Application | Type |
|---|---|---|---|
| NABG-056 | Recombinant Anti-Mouse Egfr VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
| PNBL-016 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-016) | WB, ELISA | Llama VHH |
| PNBL-017 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-017) | FuncS, ELISA, IF | Llama VHH |
| PNBL-018 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (PNBL-018) | FuncS, SPR | Llama VHH |
| HPAB-AP881-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (HPAB-AP881-YC) | ELISA, FC, IP, FuncS | Llama VHH |
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Cite This Product
To accurately reference this product in your publication, please use the following citation information:
(Creative Biolabs Cat# TAB-228CL, RRID: AB_3111887)
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.
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