Recombinant Chimeric (human/mouse) monoclonal antibody expressed in CHO binding to Human EGFR. This is a novel EGFR antibody that selectively targets a tumor-selective epitope suggesting that a mAb 806-based therapeutic would retain antitumor activity without the on-target toxicities associated with EGFR inhibition.
Host: Human
Isotype: Antibody
Applications: WB, IHC
Figure 1 ABT-806 is more potent than cetuximab at inhibiting EGFRvIII tumor growth and pEGFR expression.
Total and pEGFR status in SN0199 tumors were assessed following treatment of mice with ABT-806 at 40 mg/kg. Antibodies were administered Q3D×2, with tumors harvested 72 hour after the final dose.
Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.
Figure 2 ABT-806 downregulates tumor wild-type EGFR and pEGFR in SCC15 tumors grown as implants in mice.
IHC images of representative samples derived from harvested tumors 120 hours after treatment. IHC results were obtained by semiquantitative assessment of the
percent positive cells within viable areas across treatment groups at various time points.
Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
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CAT | Product Name | Application | Type |
TAB-750 | Anti-EGFR/HER1 Recombinant Antibody (Futuximab/Zatuximab) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
TAB-H35 | Anti-Human EGFR Recombinant Antibody (Futuximab) | IF, WB, Inhib | IgG1 - kappa |
TAB-302MZ | Human Anti-EGFR Recombinant Antibody (TAB-302MZ) | ELISA | Chimeric (mouse/human) IgG1 |
TAB-308MZ | Human Anti-EGFR Recombinant Antibody (TAB-308MZ) | FuncS | Chimeric antibody (mouse/human) |
TAB-272MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-272MZ-S(P)) | FuncS | Mouse scFv |
CAT | Product Name | Application | Type |
NABG-056 | Recombinant Anti-Mouse Egfr VHH Single Domain Antibody | ELISA, IHC, FC, FuncS | Llama VHH |
PNBL-016 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (7D12) | WB, ELISA | Llama VHH |
PNBL-017 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (9G8) | FuncS, ELISA, IF | Llama VHH |
PNBL-018 | Recombinant Anti-Human EGFR VHH Single Domain Antibody (EgA1) | FuncS, SPR | Llama VHH |
HPAB-AP881-YC | Recombinant Llama Anti-EGFR Single Domain Antibody (VHH122) | ELISA, FC, IP, FuncS | Llama VHH |
CAT | Product Name | Application | Type |
TAB-753 | Anti-EGFR Recombinant Antibody (Imgatuzumab) | Neut, ELISA, IF, IP, FuncS, FC, WB | IgG1 - kappa |
TAB-274MZ | Human Anti-EGFR Recombinant Antibody (TAB-274MZ) | FC | Humanized IgG |
TAB-274MZ-S(P) | Human Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-274MZ-S(P)) | FC | Humanized scFv |
TAB-274MZ-F(E) | Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-274MZ-F(E)) | FC | Humanized Fab |
TAB-300MZ-F(E) | Human Anti-EGFR Recombinant Antibody; Fab Fragment (TAB-300MZ-F(E)) | ELISA | Humanized Fab |
CAT | Product Name | Application | Type |
PABZ-039 | Mouse Anti-EGFR Recombinant Antibody (clone mAb528) | FC | Mouse IgG |
PABW-039 | Human Anti-EGFR Recombinant Antibody (clone Cetuximab (IMC-C225)) | FuncS | Chimeric (mouse/human) IgG |
PABC-040 | Human Anti-EGFR Recombinant Antibody (clone MR1) | Block | Human IgG |
MOB-0094MZ | Recombinant Mouse Anti-EGFR Antibody (clone FGF-R2) | ELISA, IHC-P, FC | Mouse antibody |
TAB-477CQ | Human Anti-EGFR Recombinant Antibody (clone Laprituximab) | ELISA, IHC, FC, IP, IF, WB | Chimeric (mouse/human) IgG1, κ |
CAT | Product Name | Application | Type |
TAB-0564CL-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-0564CL-S(P)) | ELISA | Mouse scFv |
TAB-303MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-303MZ-S(P)) | ELISA | Mouse scFv |
TAB-304MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-304MZ-S(P)) | ELISA | Mouse scFv |
TAB-305MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-305MZ-S(P)) | ELISA | Mouse scFv |
TAB-306MZ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (TAB-306MZ-S(P)) | ELISA | Mouse scFv |
CAT | Product Name | Application | Type |
TAB-313MZ-F(E) | Anti-Human EGFR Recombinant Antibody Fab Fragment (EG-19-11) | ELISA, FC | Human antibody |
TAB-314MZ-F(E) | Anti-Human EGFR Recombinant Antibody Fab Fragment (EG-26-11) | ELISA, FC | Human antibody |
TAB-315MZ-F(E) | Anti-Human EGFR Recombinant Antibody Fab Fragment (528) | WB, FC | Human antibody |
PABX-053 | Recombinant Human Anti-EGFR Antibody (DL11) | WB, ELISA, FuncS | IgG |
PABX-053-F (E) | Recombinant Human Anti-EGFR Antibody Fab Fragment (DL11) | WB, ELISA, FuncS | Fab |
CAT | Product Name | Application | Type |
Gly-055LC | Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Chimeric antibody (mouse/human) |
Gly-144LC | Recombinant Anti-Human EGFR Antibody (Fc glycosylation) | ELISA | Humanized antibody |
CAT | Product Name | Application | Type |
Gly-055LC-1 | Recombinant Anti-Human EGFR Antibody (Fc glycosylation/High-mannose glycosylated) | ELISA | Chimeric antibody (mouse/human) |
CAT | Product Name | Application | Type |
Gly-167LC | Recombinant Anti-Human EGFR Antibody (Non-glycosylated) | ELISA | Human antibody |
CAT | Product Name | Application | Type |
BRD-0183MZ | Chicken Anti-EGFR Polyclonal IgY | WB | Chicken antibody |
BRD-0668MZ | Chicken Anti-EGFR Polyclonal IgY | WB | Chicken antibody |
CAT | Product Name | Application | Type |
MHC-LC773 | A*0201/Human EGFR (YLNTVQPTCV) MHC Tetramer | FCM | |
MHC-LC4545 | PE-DQB1*03:02/Human EGFR (SRALEEKKGNYVVTHG) MHC Tetramer | FCM | |
MHC-YF409 | A*02:01/Human EGF-R-479 (KLFGTSGQKT) MHC Pentamer | FCM |
CAT | Product Name | Application | Type |
NEUT-722CQ | Rabbit Anti-EGFR Recombinant Antibody (clone CBL1011) | Neut | Rabbit IgG |
NEUT-723CQ | Mouse Anti-EGFR Recombinant Antibody (clone CBL931) | WB, IP, IHC, ICC, Neut | Mouse IgG1 |
NEUT-724CQ | Rabbit Anti-EGFR Recombinant Antibody (clone D1D4J) | IF, FC, WB, IP, Neut | Rabbit IgG |
CAT | Product Name | Application | Type |
MOR-1101 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone DS1101AB) | IHC-P | Rabbit IgG |
MOR-4570 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH82DS) | ELISA | Rabbit IgG |
MOR-4571 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH83DS) | WB, IF, ICC, FC | Rabbit IgG |
MOR-4675 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH189DS) | WB, IF, ICC, FC | Rabbit IgG |
MOR-4676 | Hi-Affi™ Rabbit Anti-EGFR Recombinant Antibody (clone TH190DS) | WB, IF, ICC, FC | Rabbit IgG |
CAT | Product Name | Application | Type |
HPAB-0010-YC-F(E) | Mouse Anti-EGFR Recombinant Antibody (clone L211C); Fab Fragment | ELISA, FC | Mouse Fab |
HPAB-0011-YC-F(E) | Human Anti-EGFR Recombinant Antibody (clone Pep 1); Fab Fragment | FC | Human Fab |
HPAB-0012-YC-F(E) | Human Anti-EGFR Recombinant Antibody (clone Pep 2); Fab Fragment | FC | Human Fab |
HPAB-0013-YC-F(E) | Human Anti-EGFR Recombinant Antibody (clone Pep 3); Fab Fragment | FC | Human Fab |
HPAB-0014-YC-F(E) | Human Anti-EGFR Recombinant Antibody (clone Pep 4); Fab Fragment | FC | Human Fab |
CAT | Product Name | Application | Type |
AFC-TAB-165 | Afuco™ Anti-EGFR ADCC Recombinant Antibody (Matuzumab), ADCC Enhanced | Neut, ELISA, IF, IP, FuncS, FC | ADCC enhanced antibody |
AFC-TAB-464CQ | Afuco™ Anti-EGFR ADCC Recombinant Antibody (Tomuzotuximab), ADCC Enhanced | ELISA, IHC, FC, IP, IF, FuncS | ADCC enhanced antibody |
AFC-TAB-003 | Afuco™ Anti-EGFR ADCC Recombinant Antibody (Cetuximab), ADCC Enhanced | IF, IP, Neut, FuncS, ELISA, FC | ADCC enhanced antibody |
AFC-TAB-040 | Afuco™ Anti-EGFR ADCC Recombinant Antibody (Zalutumumab), ADCC Enhanced | ELISA, FC, IP, FuncS, IF, Neut | ADCC enhanced antibody |
AFC-TAB-119 | Afuco™ Anti-EGFR ADCC Recombinant Antibody (Necitumumab), ADCC Enhanced | FC, IP, ELISA, Neut, FuncS, IF | ADCC enhanced antibody |
CAT | Product Name | Application | Type |
HPAB-S0020-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone E6.2); scFv Fragment | ELISA, Inhib | Human scFv |
HPAB-S0021-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone E6.3); scFv Fragment | ELISA, Inhib | Human scFv |
HPAB-S0022-YC-S(P) | Human Anti-EGFR Recombinant Antibody (clone E7.6.3); scFv Fragment | ELISA, Inhib, FuncS | Human scFv |
HPAB-2098-FY-S(P) | Mouse Anti-EGFR Recombinant Antibody (clone Mint5); scFv Fragment | ICC, Inhib | Mouse scFv |
HPAB-1530WJ-S(P) | Mouse Anti-EGFR Recombinant Antibody; scFv Fragment (clone 340) | ELISA, WB | Mouse scFv |
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For Research Use Only. Not For Clinical Use.
For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.