Anti-Human EGFR Therapeutic Antibody (ABT-806) (CAT#: TAB-228CL)

Recombinant Chimeric (human/mouse) monoclonal antibody expressed in CHO binding to Human EGFR. This is a novel EGFR antibody that selectively targets a tumor-selective epitope suggesting that a mAb 806-based therapeutic would retain antitumor activity without the on-target toxicities associated with EGFR inhibition.

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  • Datasheet
  • MSDS
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WB

Figure 1 ABT-806 is more potent than cetuximab at inhibiting EGFRvIII tumor growth and pEGFR expression.

Total and pEGFR status in SN0199 tumors were assessed following treatment of mice with ABT-806 at 40 mg/kg. Antibodies were administered Q3D×2, with tumors harvested 72 hour after the final dose.

Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.

IHC

Figure 2 ABT-806 downregulates tumor wild-type EGFR and pEGFR in SCC15 tumors grown as implants in mice.

IHC images of representative samples derived from harvested tumors 120 hours after treatment. IHC results were obtained by semiquantitative assessment of the
percent positive cells within viable areas across treatment groups at various time points.

Reilly, E. B., Phillips, A. C., Buchanan, F. G., Kingsbury, G., Zhang, Y., Meulbroek, J. A., ... & Gu, J. (2015). Characterization of ABT-806, a humanized tumor-specific anti-EGFR monoclonal antibody. Molecular cancer therapeutics, 14(5), 1141-1151.


Specifications

  • Host Species
  • Human
  • Derivation
  • Humanized
  • Type
  • Antibody
  • Species Reactivity
  • Human
  • Applications
  • WB, IHC
  • Related Disease
  • Cancer

Applications

  • Application Notes
  • This antibody has been reported for use in Western Blot and Immunohistochemistry.

Target

  • Alternative Names
  • EGFR; epidermal growth factor receptor; ERBB; HER1; mENA; ERBB1; PIG61; NISBD2; proto-oncogene c-ErbB-1; cell growth inhibiting protein 40; erb-b2 receptor tyrosine kinase 1; cell proliferation-inducing protein 61; receptor tyrosine-protein kinase erbB-1;

For research use only. Not intended for any clinical use. No products from Creative Biolabs may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative Biolabs.

See other products for "EGFR"

* Abbreviations
3D IHC3D Immunohistochemistry
ActivActivation
AgonistAgonist
ApopApoptosis
BABioassay
BIBioimaging
BlockBlocking
Cell ScreeningCell Screening
SeparationCell Separation
ChIPChromatin Immunoprecipitation
CMCDComplement Mediated Cell Depletion
CostimCostimulation
CytCytotoxicity
DepletionDepletion
DBDot Blot
EMElectron Microscopy
ELISAEnzyme-linked Immunosorbent Assay
ELISPOTEnzyme-linked Immunosorbent Spot
FCFlow Cytometry
FuncSFunctional Assay
GSGel Super Shift Assay
HAHemagglutination
IAImmunoassay
IBImmunoblotting
ICCImmunocytochemistry
IDImmunodiffusion
IFImmunofluorescence
IHCImmunohistochemistry
IHC-FrImmunohistochemistry-Frozen
IHC-PImmunohistochemistry-Paraffin
REImmunohistology - Resin Sections
IPImmunoprecipitation
IRMAImmunoradiometric Assay
SHIn situ hybridization
InhibInhibition
ICFCIntracellular Staining for Flow Cytometry
KO/KD-WBKnockout/Knockdown target confirmation by Western Blot
Live cell imagingLive cell imaging
CyTOF®Mass Cytometry
MeDIPMethylated DNA Immunoprecipitation
MultiplexMultiplex bead-based assay
NeutNeutralization
PPProtein Purification
PGProteogenomics
RIRadial Immunodiffusion
RIARadioimmunoassay
StimStimulation
SPRSurface Plasmon Resonance
TCTissue Culture
TBTurbidimetry
WBWestern Blot

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