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For Research Use Only. Not For Clinical Use.
Disease related genes, Human disease related genes
Membrane
Group enriched (Alveolar cells type 1, Suprabasal keratinocytes)
Low immune cell specificity
Cell line enhanced (MCF7, RT4, SK-BR-3, T-47d)
Interacts with PTK2; regulates PTK2 activation and localization (PubMed:19494199, 21637765). Interacts with ITGB3; regulates the levels of the heterodimer ITGA5-ITGB3 integrin surface expression (PubMed:16216233). Interacts with P2RX7 (via C-terminus) (PubMed:12107182). Interacts with ITGB1; the interaction may be direct or indirect and ITGB1 has a heterodimer form.