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Anti-FASN Recombinant Antibody Products
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For Research Use Only. Not For Clinical Use.
The enzyme encoded by this gene is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. In some cancer cell lines, this protein has been found to be fused with estrogen receptor-alpha (ER-alpha), in which the N-terminus of FAS is fused in-frame with the C-terminus of ER-alpha. [provided by RefSeq, Jul 2008]
Protein class
Cancer-related genes, Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Breast glandular cells, Hepatocytes, Breast myoepithelial cells, Alveolar cells type 2)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (SK-BR-3)
Interaction
Homodimer which is arranged in a head to tail fashion (PubMed:17618296, PubMed:18022563, Ref.34). Interacts with CEACAM1; this interaction is insulin and phosphorylation-dependent; reduces fatty-acid synthase activity.
Molecular function
Hydrolase, Lyase, Multifunctional enzyme, Oxidoreductase, Transferase
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