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FGF1
Anti-FGF1 Recombinant Antibody Products
- AbPlus™ Anti-FGF1 Magnetic Beads (1C9) (VS-0424-XY102)
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- Target: FGF1
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-FGF1 Immunohistochemistry Kit (VS-0325-XY836)
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- Species Reactivity: Human, Mouse, Rat
- Target: FGF1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein functions as a modifier of endothelial cell migration and proliferation, as well as an angiogenic factor. It acts as a mitogen for a variety of mesoderm- and neuroectoderm-derived cells in vitro, thus is thought to be involved in organogenesis. Multiple alternatively spliced variants encoding different isoforms have been described.
Protein class
Cancer-related genes, FDA approved drug targets, RAS pathway related proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Astrocytes, Muller glia cells, Cardiomyocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced
Interaction
Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP1. Part of a Cu(2+)-dependent multiprotein aggregate containing FGF1, S100A13 and SYT1. Interacts with SYT1. Interacts with S100A13. Interacts with LRRC59. Interacts with CSNKA, CSNKB and FIBP. While binding with LRRC59, CSNKA and FIBP seem mutually exclusive, CSNKB and FIBP may cooperatively interact with FGF1. Forms a ternary complex with FGFR1 and ITGAV:ITGB3 and induces the recruitment of PTPN11 to the complex (PubMed:20422052).
Molecular function
Developmental protein, Growth factor, Heparin-binding, Mitogen
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