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FHIT
Loading...Anti-FHIT Products
- Mouse Anti-FHIT Recombinant Antibody (VS3-CJ996) (VS3-CJ996)
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- Species Reactivity: Human
- Type: Mouse IgG1, κ
- Application: WB, FC
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- Mouse Anti-FHIT Recombinant Antibody (VS3-FY2708) (VS3-FY2708)
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- Species Reactivity: Human, Mouse, Rat
- Type: Mouse IgG
- Application: WB, FC
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- Rabbit Anti-FHIT Recombinant Antibody (VS13-YC396) (VS13-YC396)
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- Species Reactivity: Human, Rat
- Type: Rabbit IgG
- Application: WB
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a P1-P3-bis(5'-adenosyl) triphosphate hydrolase involved in purine metabolism. This gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas. The encoded protein is also a tumor suppressor, as loss of its activity results in replication stress and DNA damage. [provided by RefSeq, Aug 2017]
Protein class
Cancer-related genes, Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells, Astrocytes, Inhibitory neurons, Microglial cells)
Immune cell specificity
Immune cell enriched (naive CD4 T-cell)
Cell line specificity
Cell line enhanced (RPMI-8226, U-266/70)
Interaction
Homodimer. Interacts with UBE2I. Interacts with MDM2. Interacts with CTNNB1. Identified in a complex with CTNNB1 and LEF1.
Molecular function
Hydrolase
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