Mouse Anti-FHIT Recombinant Antibody (VS3-FY2708)
CAT#: VS3-FY2708
The anti-FHIT product is a recombinant mouse monoclonal antibody that binds to FHIT protein, a calculated weight of 16.7 kDa. It exhibits cross-reactivity with human, mouse and rat. This monoclonal antibody is potential for conducting research on Hereditary Clear Cell Renal Cell Carcinoma and Sporadic Breast cancer. The antibody can be utilized for detection of FHIT by Western Blot, Flow cytometry.
Gene Expression
Subcellular Location
Figure 1 IF staining of human cell line HEK 293
Immunofluorescent staining of human cell line HEK 293 shows localization to nucleoli fibrillar center & plasma membrane.
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/18909/if_selected.jpg
Normal Tissue
Figure 2 Cerebral cortex
Endothelial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous Glial cells Staining: Medium Intensity: Moderate Quantity: 75%-25% Location: Cytoplasmic/ membranous nuclear Neuronal cells Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous Neuropil Staining: Medium Intensity: Moderate Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2684/6605_B_8_5.jpg
Normal Tissue
Figure 3 Colon
Endocrine cells Staining: Medium Intensity: Moderate Enterocytes Staining: Medium Intensity: Moderate Quantity:>75% Enterocytes - Goblet cells Staining: Medium Intensity: Moderate Quantity:>75% Mucosal lymphoid cells Staining: Low Intensity: Moderate Quantity: <25% Peripheral nerve/ganglion Staining: Low Intensity: Weak
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2684/6605_A_7_3.jpg
Normal Tissue
Figure 4 Kidney
Cells in tubules Staining: High Intensity: Strong Quantity:>75% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2684/6605_A_7_5.jpg
Normal Tissue
Figure 5 Testis
Leydig cells Staining: Medium Intensity: Moderate Quantity:>75% Sertoli cells Staining: Medium Intensity: Moderate Quantity:>75%
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2684/6605_A_5_6.jpg
Normal Tissue
Figure 6 Lymph node
Non-germinal center cells Staining: Low Intensity: Moderate Quantity: <25% Location: Cytoplasmic/ membranous
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/images/2684/6605_A_8_8.jpg
RNA Expression
Figure 7 RNA cell line category: Cell line enhanced (RPMI-8226, U-266/70)
Cell lines ordered by descending RNA expression order
* Image credit: Image credit: Human Protein Atlas v21.proteinatlas.org/ENSG00000189283-FHIT
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Specifications
- Host Species
- Mouse
- Type
- Mouse IgG
- Specificity
- Fragile histidine triad of human, mouse and rat origins
- Species Reactivity
- Human, Mouse, Rat
- Applications
- WB, FC
- Conjugate
- Unconjugated, FITC
- MW
- The molecular weight of the target protein is approximately 16.7 kDa.
- Related Disease
- Hereditary Clear Cell Renal Cell Carcinoma and Sporadic Breast Cancer
Product Property
- Clonality
- Monoclonal Antibody
- Format
- Liquid
- Concentration
- Please refer to the vial label for the specific concentration.
- Storage
- Centrifuge briefly prior to opening vial. Store at +4°C for short term (1-2 weeks). Aliquot and store at -20°C for long term. Avoid repeated freeze/thaw cycles.
Applications
- Application Notes
- Western Blot: 1/500-1/2000
Flow cytometry: 1/10-1/25
Target
- Alternative Names
- Fragile Histidine Triad; Diadenosine 5,5-P1,P3-Triphosphate Hydrolase; Dinucleosidetriphosphatase; AP3A Hydrolase; AP3Aase; Fragile Histidine Triad Protein
- Gene ID
- 2272
- UniProt ID
- P49789
- Cellular Localization
- Cytoplasm, Mitochondrion, Nucleus
- Post Translation Modifications
- Phosphorylation at Tyr-114 by SRC is required for induction of apoptosis.
Modification sites at PhosphoSitePlus
Modification sites at neXtProt
- Protein Refseq
- NP_001159715.1; NP_001307828.1; NP_001307829.1; NP_001307830.1; NP_001341518.1
- Function
- Exhibits adenylylsulfatase activity, hydrolyzing adenosine 5'-phosphosulfate to yield AMP and sulfate (PubMed:18694747).
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:18694747).
Exhibits adenylylsulfate-ammonia adenylyltransferase, catalyzing the ammonolysis of adenosine 5'-phosphosulfate resulting in the formation of adenosine 5'-phosphoramidate.
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Downloadable Resources
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Product Notes
This is a product of Creative Biolabs' Hi-Affi™ recombinant antibody portfolio, which has several benefits including:
• Increased sensitivity
• Confirmed specificity
• High repeatability
• Excellent batch-to-batch consistency
• Sustainable supply
• Animal-free production
See more details about Hi-Affi™ recombinant antibody benefits.
Datasheet
MSDS
COA
Certificate of Analysis LookupTo download a Certificate of Analysis, please enter a lot number in the search box below. Note: Certificate of Analysis not available for kit components.
Lot Number:
Secondary Antibody
- CAT
- Product Name
Isotype Control
- CAT
- Product Name
See other products for "FHIT"
Select a product category from the dropdown menu below to view related products.
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOB-0740CT | Recombinant Mouse anti-Human FHIT Monoclonal antibody (EML2146) | WB | |
| VS3-CJ996 | Mouse Anti-FHIT Recombinant Antibody (VS3-CJ996) | WB, FC | Mouse IgG1, κ |
| VS13-YC396 | Rabbit Anti-FHIT Recombinant Antibody (VS13-YC396) | WB | Rabbit IgG |
| CAT | Product Name | Application | Type |
|---|---|---|---|
| MOR-1304 | Hi-Affi™ Rabbit Anti-FHIT Recombinant Antibody (clone DS1304AB) | WB | Rabbit IgG |
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